Akineton and Hypothyroidism - a phase IV clinical study of FDA data

Summary:

Hypothyroidism is reported as a side effect among people who take Akineton (biperiden hydrochloride), especially for people who are female, 10-19 old, also take Abilify, and have Psychotic disorder.

The phase IV clinical study analyzes which people have Hypothyroidism when taking Akineton. It is created by eHealthMe based on reports of 6,101 people who have side effects when taking Akineton from the FDA, and is updated regularly.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

What is Hypothyroidism?

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,617 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 18, 2026

6,101 people reported to have side effects when taking Akineton.
Among them, 18 people (0.3%) have Hypothyroidism.

Among these 18 people:

What is the gender of people who have Hypothyroidism when taking Akineton? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Hypothyroidism when taking Akineton? *

What are other drugs people take besides Akineton? *

Abilify: 10 people, 55.56%
Invega: 8 people, 44.44%
Paliperidone Palmitate: 3 people, 16.67%
Seroquel: 2 people, 11.11%
Geodon: 2 people, 11.11%
Lorazepam: 2 people, 11.11%
Risperdal: 2 people, 11.11%
Zyprexa: 2 people, 11.11%
Valproate Sodium: 2 people, 11.11%
Sunitinib Malate: 1 person, 5.56%

What are other side effects people have besides Hypothyroidism? *

Weight Increased: 10 people, 55.56%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 8 people, 44.44%
Personality Disorder: 8 people, 44.44%
Psychotic Disorder: 8 people, 44.44%
Suicide Attempt: 8 people, 44.44%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 11.11%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 2 people, 11.11%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 11.11%
Depression: 2 people, 11.11%
Swallowing Difficulty: 2 people, 11.11%

What are the existing conditions these people have? *

Psychotic Disorder: 7 people, 38.89%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 16.67%
Bipolar Disorder (mood disorder): 2 people, 11.11%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 11.11%
Diabetes: 1 person, 5.56%
Affective Disorder (mental disorder): 1 person, 5.56%
Anal Cancer Stage Iv: 1 person, 5.56%
Arrhythmias (irregular heartbeat): 1 person, 5.56%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 5.56%
Depression: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Akineton and have Hypothyroidism?

- Check whether Hypothyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Akineton:

Akineton (6,140 reports)

Hypothyroidism treatments and more:

Hypothyroidism (168,071 reports)

Browse all side effects of Akineton:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypothyroidism:

Hypothyroidism (1,617 drugs)

Browse all the conditions that are associated with Hypothyroidism:

Hypothyroidism (2,600 conditions)

Related publications that referenced our studies

Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .
Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .

How the study uses the data?

The study uses data from the FDA. It is based on biperiden hydrochloride (the active ingredients of Akineton) and Akineton (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.