Aldactazide and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Aldactazide (hydrochlorothiazide; spironolactone), especially for people who are female, 60+ old, also take Neurontin, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Stroke when taking Aldactazide. It is created by eHealthMe based on reports of 1,564 people who have side effects when taking Aldactazide from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,309 drugs and 3,031 conditions by eHealthMe. Check the latest studies of Stroke.

On Jul, 25, 2026

1,564 people reported to have side effects when taking Aldactazide.
Among them, 25 people (1.6%) have Stroke.

Among these 25 people:

What is the gender of people who have Stroke when taking Aldactazide? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Stroke when taking Aldactazide? *

What are other drugs people take besides Aldactazide? *

What are other side effects people have besides Stroke? *

Acute Kidney Failure: 6 people, 24.00%
Insomnia (sleeplessness): 5 people, 20.00%
Drug Ineffective: 4 people, 16.00%
Depression: 4 people, 16.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 16.00%
Stress And Anxiety: 4 people, 16.00%
Speech Disorder: 4 people, 16.00%
Mitral Valve Incompetence (inefficient heart valve): 4 people, 16.00%
Cardiac Failure Congestive: 4 people, 16.00%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 16.00%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 24.00%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 4 people, 16.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 12.00%
Arrhythmias (irregular heartbeat): 3 people, 12.00%
Oedema Peripheral (superficial swelling): 3 people, 12.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 12.00%
Diabetes: 3 people, 12.00%
Heart Attack: 3 people, 12.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactazide:

Aldactazide (1,597 reports)

Stroke treatments and more:

Stroke (334,635 reports)

How severe was Stroke and when was it recovered:

Stroke in Aldactazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; spironolactone:

Stroke and drugs with ingredients of hydrochlorothiazide; spironolactone

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aldactazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,309 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,031 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; spironolactone (the active ingredients of Aldactazide) and Aldactazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.