Aleve and Joint destruction - a phase IV clinical study of FDA data

Summary:

Joint destruction is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 30-39 old, also take Orencia, and have Blood pressure abnormal.

The phase IV clinical study analyzes which people have Joint destruction when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,277 Aleve users. Check the latest studies of Aleve.

What is Joint destruction?

Joint destruction (joint damage) is found to be associated with 152 drugs and 410 conditions by eHealthMe. Check the latest studies of Joint destruction.

On Feb, 13, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 16 people (0.02%) have Joint destruction.

Among these 16 people:

What is the gender of people who have Joint destruction when taking Aleve? *

female: 100 %
male: 0.0 %

What is the age of people who have Joint destruction when taking Aleve? *

What are other drugs people take besides Aleve? *

Enbrel: 9 people, 56.25%
Orencia: 9 people, 56.25%
Humira: 8 people, 50.00%
Premarin: 7 people, 43.75%
Xeljanz: 7 people, 43.75%
Actemra: 7 people, 43.75%
Vitamin B12: 7 people, 43.75%
Triamcinolone Acetonide: 6 people, 37.50%
Folic Acid: 6 people, 37.50%
Methotrexate: 6 people, 37.50%

What are other side effects people have besides Joint destruction? *

Diarrhea: 9 people, 56.25%
Mobility Decreased (ability to move is reduced): 9 people, 56.25%
Nausea And Vomiting: 9 people, 56.25%
Loss Of Consciousness: 9 people, 56.25%
Immunodeficiency: 9 people, 56.25%
Weight Loss: 9 people, 56.25%
Pleural Effusion (water on the lungs): 9 people, 56.25%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 9 people, 56.25%
Psoriasis (immune-mediated disease that affects the skin): 9 people, 56.25%
Hypotension (abnormally low blood pressure): 9 people, 56.25%

What are the existing conditions these people have? *

Weight Increased: 7 people, 43.75%
Thyroid Diseases: 7 people, 43.75%
Blood Pressure Abnormal: 7 people, 43.75%
Autonomic Nervous System Imbalance (autonomic nervous system is of net equal emphasis): 6 people, 37.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 25.00%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 4 people, 25.00%
Seasonal Allergy (allergic condition due to certain season): 2 people, 12.50%
Allergic Rhinitis: 2 people, 12.50%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.25%
Neck Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Joint destruction?

- Check whether Joint destruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,277 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint destruction:

Joint destruction (152 drugs)

Browse all the conditions that are associated with Joint destruction:

Joint destruction (410 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.