Methylphenidate and Restasis drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Restasis (cyclosporine). Common drug interactions include migraine among females and asthenia among males.
The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Restasis. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.
What is Methylphenidate?
Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
97 people who take Methylphenidate and Restasis together, and have interactions are studied.

What are the common drug interactions of Methylphenidate and Restasis, by gender? *:
female:
- Migraine (headache)
- Mobility decreased (ability to move is reduced)
- Nasopharyngitis (inflammation of the nasopharynx)
- Osteoarthritis (a joint disease caused by cartilage loss in a joint)
- Pain
- Abdominal discomfort
- Addison's disease (addison's disease, a hormonal disorder disease)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Ankle fracture
- Anxiety
male:
- Asthenia (weakness)
- Fatigue (feeling of tiredness)
- Ascites (accumulation of fluid in the abdominal cavity)
- Blood potassium decreased
- Blood pressure decreased
- Blood sodium decreased
- Body temperature increased
- Bradycardia (abnormally slow heart action)
- Cardiac arrest
- Confusional state
What are the common drug interactions of Methylphenidate and Restasis, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Hypotension (abnormally low blood pressure)
- Body temperature increased
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Fibromyalgia (a long-term condition which causes pain all over the body)
- Hospitalisation
- Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
- Premature delivery
- Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
- Affective disorder (mental disorder)
- Anal abscess
40-49:
- Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
- Hypertension (high blood pressure)
- Pruritus (severe itching of the skin)
- Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
- Therapeutic response unexpected
- Vitamin d decreased
- Abdominal hernia
- Asthenia (weakness)
- Chest pain
50-59:
- Neuropathy peripheral (surface nerve damage)
- Depression
- Drug hypersensitivity
- Drug ineffective
- Gastric disorder (disease of stomach)
- Muscle spasms (muscle contraction)
- Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
- Surgery
- Fluid retention (an abnormal accumulation of fluid in the blood)
- Bradycardia (abnormally slow heart action)
60+:
- Gait disturbance
- Herpes zoster
- Headache (pain in head)
- Malaise (a feeling of general discomfort or uneasiness)
- Muscle spasms (muscle contraction)
- Cellulitis (infection under the skin)
- Confusional state
- Diarrhoea
- Drug dependence
- Epistaxis (bleed from the nose)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 83 people, 85.57%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 60 people, 61.86%
- Drowsiness: 19 people, 19.59%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.25%
- Thyroid Diseases: 7 people, 7.22%
- High Blood Cholesterol: 6 people, 6.19%
- Pain: 5 people, 5.15%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.15%
- Bone Disorder: 5 people, 5.15%
* Approximation only. Some reports may have incomplete information.
Do you take Methylphenidate and Restasis?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Methylphenidate (8,216 reports)
- Restasis (35,199 reports)
Browse all drug interactions of Methylphenidate and Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Methylphenidate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Methylphenidate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on methylphenidate and cyclosporine (the active ingredients of Methylphenidate and Restasis, respectively), and Methylphenidate and Restasis (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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