Aleve and Malabsorption - a phase IV clinical study of FDA data

Summary:

Malabsorption is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Benicar, and have High blood pressure.

The phase IV clinical study analyzes which people have Malabsorption when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,277 Aleve users. Check the latest studies of Aleve.

What is Malabsorption?

Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract) is found to be associated with 708 drugs and 1,087 conditions by eHealthMe. Check the latest studies of Malabsorption.



On Jan, 07, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 27 people (0.04%) have Malabsorption.

Could Aleve cause Malabsorption?

Among these 27 people:

How long have people been on Aleve when they have Malabsorption? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Malabsorption when taking Aleve? *

  • female: 83.33 %
  • male: 16.67 %

What is the age of people who have Malabsorption when taking Aleve? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 28.57 %
  • 50-59: 28.57 %
  • 60+: 42.86 %

What are other drugs people take besides Aleve? *

  1. Benicar Hct: 18 people, 66.67%
  2. Benicar: 18 people, 66.67%
  3. Tylenol: 4 people, 14.81%
  4. Protonix: 4 people, 14.81%
  5. Vitamin D3: 3 people, 11.11%
  6. Calcium: 3 people, 11.11%
  7. Coreg: 3 people, 11.11%
  8. Crestor: 3 people, 11.11%
  9. Prilosec: 2 people, 7.41%
  10. Cozaar: 2 people, 7.41%

What are other side effects people have besides Malabsorption? *

  1. Dizziness: 6 people, 22.22%
  2. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 6 people, 22.22%
  3. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 5 people, 18.52%
  4. Constipation: 5 people, 18.52%
  5. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 5 people, 18.52%
  6. Stress And Anxiety: 5 people, 18.52%
  7. Depression: 4 people, 14.81%
  8. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 4 people, 14.81%
  9. Lactose Intolerance (inability to digest lactose): 4 people, 14.81%
  10. Dyspnea (difficult or laboured breathing): 4 people, 14.81%

What are the existing conditions these people have? *

  1. High Blood Pressure: 22 people, 81.48%
  2. Back Pain: 3 people, 11.11%
  3. Joint Pain: 3 people, 11.11%
  4. Diabetes: 2 people, 7.41%
  5. Immunodeficiency Common Variable: 2 people, 7.41%
  6. Diarrhea: 2 people, 7.41%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 7.41%
  8. Stress And Anxiety: 2 people, 7.41%
  9. High Blood Cholesterol: 2 people, 7.41%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Malabsorption?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Malabsorption treatments and more:

How severe was Malabsorption and when was it recovered:

Expand to all the drugs that have ingredients of naproxen sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malabsorption:

Browse all the conditions that are associated with Malabsorption:

Drugs similar to Aleve and Malabsorption :


How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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