Aleve and Temperature intolerance - a phase IV clinical study of FDA data

Summary:

Temperature intolerance is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Vitamin D3, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Temperature intolerance when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Temperature intolerance?

Temperature intolerance (inability to go in temperature) is found to be associated with 819 drugs and 754 conditions by eHealthMe. Check the latest studies of Temperature intolerance.

On Jul, 25, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 53 people (0.08%) have Temperature intolerance.

Could Aleve cause Temperature intolerance?

Among these 53 people:

How long have people been on Aleve when they have Temperature intolerance? *

What is the gender of people who have Temperature intolerance when taking Aleve? *

female: 60.38 %
male: 39.62 %

What is the age of people who have Temperature intolerance when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Temperature intolerance? *

Fatigue (feeling of tiredness): 34 people, 64.15%
Depression: 26 people, 49.06%
Dizziness: 24 people, 45.28%
Hypoaesthesia (reduced sense of touch or sensation): 18 people, 33.96%
Joint Pain: 18 people, 33.96%
Nausea (feeling of having an urge to vomit): 17 people, 32.08%
Hair Loss: 16 people, 30.19%
Back Pain: 16 people, 30.19%
Pain In Extremity: 15 people, 28.30%
Nausea And Vomiting: 15 people, 28.30%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 19 people, 35.85%
Prostate Cancer: 11 people, 20.75%
Gait Disturbance: 10 people, 18.87%
Stress And Anxiety: 8 people, 15.09%
Neuralgia (pain in one or more nerves): 4 people, 7.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.55%
Drowsiness: 4 people, 7.55%
Seasonal Allergy (allergic condition due to certain season): 4 people, 7.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.55%
Apathy: 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Temperature intolerance?

- Check whether Temperature intolerance is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Temperature intolerance:

Temperature intolerance (819 drugs)

Browse all the conditions that are associated with Temperature intolerance:

Temperature intolerance (754 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.