Allegra and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Allegra (fexofenadine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Singulair, and have Hypersensitivity.

The phase IV clinical study analyzes which people have Major depression when taking Allegra. It is created by eHealthMe based on reports of 73,095 people who have side effects when taking Allegra from the FDA, and is updated regularly.

What is Allegra?

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. eHealthMe is studying from 75,498 Allegra users. Check the latest studies of Allegra.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 12, 2026

73,095 people reported to have side effects when taking Allegra.
Among them, 69 people (0.09%) have Major depression.

Among these 69 people:

How long have people been on Allegra when they have Major depression? *

What is the gender of people who have Major depression when taking Allegra? *

female: 63.49 %
male: 36.51 %

What is the age of people who have Major depression when taking Allegra? *

What are other drugs people take besides Allegra? *

What are other side effects people have besides Major depression? *

Fatigue (feeling of tiredness): 23 people, 33.33%
Stress And Anxiety: 19 people, 27.54%
High Blood Pressure: 17 people, 24.64%
Headache (pain in head): 15 people, 21.74%
Suicidal Ideation: 14 people, 20.29%
Back Pain: 14 people, 20.29%
Dyspnea (difficult or laboured breathing): 13 people, 18.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 18.84%
Chest Pain: 13 people, 18.84%
Joint Pain: 13 people, 18.84%

What are the existing conditions these people have? *

Hypersensitivity: 11 people, 15.94%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 14.49%
High Blood Pressure: 9 people, 13.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.14%
Stress And Anxiety: 6 people, 8.70%
Asthma: 6 people, 8.70%
Pain: 5 people, 7.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 7.25%
Drowsiness: 4 people, 5.80%
Cough: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

Do you take Allegra and have Major depression?

- Check whether Major depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Allegra:

Allegra (75,498 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Allegra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fexofenadine hydrochloride (the active ingredients of Allegra) and Allegra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.