Alprazolam and Negativism - a phase IV clinical study of FDA data

Summary:

Negativism is reported as a side effect among people who take Alprazolam (alprazolam), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Promazine Hydrochloride, and have Insomnia.

The phase IV clinical study analyzes which people have Negativism when taking Alprazolam. It is created by eHealthMe based on reports of 132,238 people who have side effects when taking Alprazolam from the FDA, and is updated regularly.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 134,864 Alprazolam users. Check the latest studies of Alprazolam.

What is Negativism?

Negativism (negative thoughts) is found to be associated with 76 drugs and 234 conditions by eHealthMe. Check the latest studies of Negativism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

132,238 people reported to have side effects when taking Alprazolam.
Among them, 15 people (0.01%) have Negativism.

Among these 15 people:

How long have people been on Alprazolam when they have Negativism? *

What is the gender of people who have Negativism when taking Alprazolam? *

female: 20 %
male: 80 %

What is the age of people who have Negativism when taking Alprazolam? *

What are other drugs people take besides Alprazolam? *

Metformin: 2 people, 13.33%
Zolpidem: 2 people, 13.33%
Akineton: 2 people, 13.33%
Haldol: 2 people, 13.33%
Escitalopram: 2 people, 13.33%
Risperidone: 2 people, 13.33%
Diazepam: 2 people, 13.33%
Maprotiline Hydrochloride: 2 people, 13.33%
Promazine Hydrochloride: 2 people, 13.33%
Zyprexa: 1 person, 6.67%

What are other side effects people have besides Negativism? *

Aggression: 11 people, 73.33%
Agitation (state of anxiety or nervous excitement): 9 people, 60.00%
Alcoholism (problems with alcohol): 6 people, 40.00%
Thinking Abnormal: 6 people, 40.00%
Lactic Acidosis (low ph in body tissues): 5 people, 33.33%
Sopor (sleep): 5 people, 33.33%
Fear: 4 people, 26.67%
Hyporesponsive To Stimuli (abnormally low degree of responsiveness on an agent, action, or condition): 4 people, 26.67%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 4 people, 26.67%
Abnormal Behavior: 3 people, 20.00%

What are the existing conditions these people have? *

Insomnia (sleeplessness): 3 people, 20.00%
Galactorrhea (secretion of breast milk in men): 2 people, 13.33%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 13.33%
Alcoholism (problems with alcohol): 2 people, 13.33%
Fever: 1 person, 6.67%
Agitation (state of anxiety or nervous excitement): 1 person, 6.67%
Depression: 1 person, 6.67%
Dyslipidaemia (abnormal amount of lipids): 1 person, 6.67%
Enlarged Prostate: 1 person, 6.67%
Euphoric Mood (excessively happy but may become angry or irritable): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Alprazolam and have Negativism?

- Check whether Negativism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Alprazolam:

Alprazolam (134,864 reports)

Negativism treatments and more:

Negativism (960 reports)

Browse all side effects of Alprazolam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Negativism:

Negativism (76 drugs)

Browse all the conditions that are associated with Negativism:

Negativism (234 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alprazolam (the active ingredients of Alprazolam) and Alprazolam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.