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Amitiza and Trigeminal neuralgia - a phase IV clinical study of FDA data

Summary:

Trigeminal neuralgia is reported as a side effect among people who take Amitiza (lubiprostone), especially for people who are female, 50-59 old, also take Clonazepam, and have Arthritis.

The phase IV clinical study analyzes which people have Trigeminal neuralgia when taking Amitiza. It is created by eHealthMe based on reports of 10,225 people who have side effects when taking Amitiza from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Trigeminal neuralgia?

Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation) is found to be associated with 421 drugs and 756 conditions by eHealthMe. Check the latest studies of Trigeminal neuralgia.

On Aug, 07, 2026

10,225 people reported to have side effects when taking Amitiza.
Among them, 13 people (0.13%) have Trigeminal neuralgia.

Could Amitiza cause Trigeminal neuralgia?

Among these 13 people:

What is the gender of people who have Trigeminal neuralgia when taking Amitiza? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Trigeminal neuralgia when taking Amitiza? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 50 %
  • 60+: 40 %

What are other drugs people take besides Amitiza? *

  1. Neurontin: 7 people, 53.85%
  2. Clonazepam: 7 people, 53.85%
  3. Protonix: 6 people, 46.15%
  4. Zantac: 5 people, 38.46%
  5. Faslodex: 5 people, 38.46%
  6. Monopril: 5 people, 38.46%
  7. Mirapex: 5 people, 38.46%
  8. Vicodin: 5 people, 38.46%
  9. Megace: 5 people, 38.46%
  10. Lorazepam: 5 people, 38.46%

What are other side effects people have besides Trigeminal neuralgia? *

  1. Pain: 11 people, 84.62%
  2. Dyspnea (difficult or laboured breathing): 11 people, 84.62%
  3. Fall: 10 people, 76.92%
  4. Fatigue (feeling of tiredness): 10 people, 76.92%
  5. Weight Decreased: 9 people, 69.23%
  6. Headache (pain in head): 9 people, 69.23%
  7. Nausea And Vomiting: 9 people, 69.23%
  8. Nausea (feeling of having an urge to vomit): 9 people, 69.23%
  9. Weakness: 9 people, 69.23%
  10. Hypoaesthesia (reduced sense of touch or sensation): 9 people, 69.23%

What are the existing conditions these people have? *

  1. Pain: 5 people, 38.46%
  2. Metastases To Bone (cancer spreads to bone): 5 people, 38.46%
  3. High Blood Pressure: 5 people, 38.46%
  4. Breast Cancer: 5 people, 38.46%
  5. Bone Pain: 5 people, 38.46%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 38.46%
  7. Nervousness: 4 people, 30.77%
  8. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 30.77%
  9. High Blood Cholesterol: 4 people, 30.77%
  10. Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 4 people, 30.77%

* Approximation only. Some reports may have incomplete information.

Do you take Amitiza and have Trigeminal neuralgia?

- Check whether Trigeminal neuralgia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitiza:

Trigeminal neuralgia treatments and more:

How severe was Trigeminal neuralgia and when was it recovered:

Expand to all the drugs that have ingredients of lubiprostone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Trigeminal neuralgia:

Browse all the conditions that are associated with Trigeminal neuralgia:

How the study uses the data?

The study uses data from the FDA. It is based on lubiprostone (the active ingredients of Amitiza) and Amitiza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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