Amlodipine and Brain midline shift - a phase IV clinical study of FDA data

Summary:

Brain midline shift is reported as a side effect among people who take Amlodipine (amlodipine besylate), especially for people who are female, 60+ old, also take Paracetamol, and have Pain.

The phase IV clinical study analyzes which people have Brain midline shift when taking Amlodipine. It is created by eHealthMe based on reports of 346,875 people who have side effects when taking Amlodipine from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,833 Amlodipine users. Check the latest studies of Amlodipine.

What is Brain midline shift?

Brain midline shift is found to be associated with 84 drugs and 214 conditions by eHealthMe. Check the latest studies of Brain midline shift.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

346,875 people reported to have side effects when taking Amlodipine.
Among them, 26 people (0.01%) have Brain midline shift.

Could Amlodipine cause Brain midline shift?

Among these 26 people:

What is the gender of people who have Brain midline shift when taking Amlodipine? *

female: 68 %
male: 32 %

What is the age of people who have Brain midline shift when taking Amlodipine? *

What are other drugs people take besides Amlodipine? *

What are other side effects people have besides Brain midline shift? *

Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 9 people, 34.62%
Subdural Haematoma (blood collects between the skull and the surface of the brain): 9 people, 34.62%
Haemorrhage Intracranial (bleeding within the skull): 8 people, 30.77%
Swallowing Difficulty: 8 people, 30.77%
Subdural Haemorrhage (bleeding between the skull and the surface of the brain): 7 people, 26.92%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 6 people, 23.08%
Cerebral Haemorrhage (bleeding within the brain): 5 people, 19.23%
Fall: 5 people, 19.23%
Headache (pain in head): 4 people, 15.38%
Confusional State: 3 people, 11.54%

What are the existing conditions these people have? *

Pain: 6 people, 23.08%
Constipation: 5 people, 19.23%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 15.38%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 11.54%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 11.54%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 7.69%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 7.69%
Type 2 Diabetes: 2 people, 7.69%
Bone Marrow Failure: 1 person, 3.85%
Cancer Pain: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and have Brain midline shift?

- Check whether Brain midline shift is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amlodipine:

Amlodipine (354,833 reports)

Browse all side effects of Amlodipine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain midline shift:

Brain midline shift (84 drugs)

Browse all the conditions that are associated with Brain midline shift:

Brain midline shift (214 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.