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Amlodipine and Mitral valve prolapse - a phase IV clinical study of FDA data

Summary:

Mitral valve prolapse is reported as a side effect among people who take Amlodipine (amlodipine besylate), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Mitral valve prolapse when taking Amlodipine. It is created by eHealthMe based on reports of 346,875 people who have side effects when taking Amlodipine from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,833 Amlodipine users. Check the latest studies of Amlodipine.

What is Mitral valve prolapse?

Mitral valve prolapse (heart's mitral valve doesn't work well) is found to be associated with 504 drugs and 859 conditions by eHealthMe. Check the latest studies of Mitral valve prolapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

346,875 people reported to have side effects when taking Amlodipine.
Among them, 28 people (0.01%) have Mitral valve prolapse.

Could Amlodipine cause Mitral valve prolapse?

Among these 28 people:

How long have people been on Amlodipine when they have Mitral valve prolapse? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

What is the gender of people who have Mitral valve prolapse when taking Amlodipine? *

  • female: 55.56 %
  • male: 44.44 %

What is the age of people who have Mitral valve prolapse when taking Amlodipine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 8.33 %
  • 50-59: 29.17 %
  • 60+: 62.5 %

What are other drugs people take besides Amlodipine? *

  1. Xyrem: 5 people, 17.86%
  2. Gabapentin: 4 people, 14.29%
  3. Aspirin: 4 people, 14.29%
  4. Digoxin: 3 people, 10.71%
  5. Duloxetine Hydrochloride: 3 people, 10.71%
  6. Atorvastatin Calcium: 3 people, 10.71%
  7. Enalapril Maleate: 3 people, 10.71%
  8. Raxar: 3 people, 10.71%
  9. Loratadine: 3 people, 10.71%
  10. Warfarin Sodium: 3 people, 10.71%

What are other side effects people have besides Mitral valve prolapse? *

  1. Pain In Extremity: 8 people, 28.57%
  2. Inflammation: 7 people, 25.00%
  3. Cushing's Syndrome (obesity, a rounded face, increased fat): 7 people, 25.00%
  4. Stress And Anxiety: 7 people, 25.00%
  5. Pulse Absent: 6 people, 21.43%
  6. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 6 people, 21.43%
  7. Paleness (unusual lightness of skin colour): 6 people, 21.43%
  8. Mitral Valve Incompetence (inefficient heart valve): 6 people, 21.43%
  9. Speech Disorder: 6 people, 21.43%
  10. Speech Impairment (Adult) (inability to speak (adult)): 6 people, 21.43%

What are the existing conditions these people have? *

  1. Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls): 5 people, 17.86%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 17.86%
  3. Osteoporosis (bones weak and more likely to break): 3 people, 10.71%
  4. Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 3 people, 10.71%
  5. Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 10.71%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 10.71%
  7. Gastric Disorder (disease of stomach): 3 people, 10.71%
  8. Drowsiness: 3 people, 10.71%
  9. Skin Ulcer: 2 people, 7.14%
  10. Depression: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and have Mitral valve prolapse?

- Check whether Mitral valve prolapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amlodipine:

Mitral valve prolapse treatments and more:

How severe was Mitral valve prolapse and when was it recovered:

Expand to all the drugs that have ingredients of amlodipine besylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amlodipine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve prolapse:

Browse all the conditions that are associated with Mitral valve prolapse:

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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