Amlodipine and Optic disc disorder - a phase IV clinical study of FDA data

Summary:

Optic disc disorder is reported as a side effect among people who take Amlodipine (amlodipine besylate), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Ramipril, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Optic disc disorder when taking Amlodipine. It is created by eHealthMe based on reports of 346,875 people who have side effects when taking Amlodipine from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,830 Amlodipine users. Check the latest studies of Amlodipine.

What is Optic disc disorder?

Optic disc disorder (disease of optic disc of eye) is found to be associated with 42 drugs and 166 conditions by eHealthMe. Check the latest studies of Optic disc disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

346,875 people reported to have side effects when taking Amlodipine.
Among them, 21 people (0.01%) have Optic disc disorder.

Could Amlodipine cause Optic disc disorder?

Among these 21 people:

How long have people been on Amlodipine when they have Optic disc disorder? *

What is the gender of people who have Optic disc disorder when taking Amlodipine? *

female: 27.78 %
male: 72.22 %

What is the age of people who have Optic disc disorder when taking Amlodipine? *

What are other drugs people take besides Amlodipine? *

Ramipril: 12 people, 57.14%
Acetaminophen: 9 people, 42.86%
Nitrofurantoin: 7 people, 33.33%
Norvasc: 5 people, 23.81%
Aspirin: 4 people, 19.05%
Levofloxacin: 3 people, 14.29%
Nexium: 3 people, 14.29%
Nitrofurantoin Macrocrystalline: 3 people, 14.29%
Paracetamol: 3 people, 14.29%
Losartan: 3 people, 14.29%

What are other side effects people have besides Optic disc disorder? *

Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 13 people, 61.90%
Visual Acuity Reduced (reduced clearness of vision): 12 people, 57.14%
Cataract (clouding of the lens inside the eye): 11 people, 52.38%
Type 2 Diabetes: 5 people, 23.81%
Punctate Keratitis (inflammation of the cornea with tiny spots): 3 people, 14.29%
Photophobia (extreme sensitivity to light): 3 people, 14.29%
Dry Eyes (lack of adequate tears): 3 people, 14.29%
Diplopia (double vision): 3 people, 14.29%
Iris Disorder: 3 people, 14.29%
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest): 3 people, 14.29%

What are the existing conditions these people have? *

Urinary Tract Infection: 3 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 14.29%
Constipation: 2 people, 9.52%
Reversible Posterior Leukoencephalopathy Syndrome (a brain disease with generalized seizures and headache): 1 person, 4.76%
Hepatitis B: 1 person, 4.76%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 4.76%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Amlodipine and have Optic disc disorder?

- Check whether Optic disc disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amlodipine:

Amlodipine (354,830 reports)

Browse all side effects of Amlodipine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic disc disorder:

Optic disc disorder (42 drugs)

Browse all the conditions that are associated with Optic disc disorder:

Optic disc disorder (166 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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