Amoxicillin and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Amoxicillin (amoxicillin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Eczema.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Amoxicillin. It is created by eHealthMe based on reports of 95,831 people who have side effects when taking Amoxicillin from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 365 drugs and 558 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

95,831 people reported to have side effects when taking Amoxicillin.
Among them, 41 people (0.04%) have Appendicitis perforated.

Could Amoxicillin cause Appendicitis perforated?

Among these 41 people:

How long have people been on Amoxicillin when they have Appendicitis perforated? *

What is the gender of people who have Appendicitis perforated when taking Amoxicillin? *

female: 22.5 %
male: 77.5 %

What is the age of people who have Appendicitis perforated when taking Amoxicillin? *

What are other drugs people take besides Amoxicillin? *

What are other side effects people have besides Appendicitis perforated? *

Abdominal Pain: 28 people, 68.29%
Joint Pain: 17 people, 41.46%
Fever: 17 people, 41.46%
Intervertebral Disc Degeneration (spinal disc degeneration): 17 people, 41.46%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 16 people, 39.02%
Neuroendocrine Carcinoma (cancer tumour that arise from cells of the endocrine (hormonal) and nervous systems): 16 people, 39.02%
Lump In The Abdomen (an area of swelling or growth on abdomen): 16 people, 39.02%
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 16 people, 39.02%
Intervertebral Disc Protrusion (spinal disc protrusion): 16 people, 39.02%
Swallowing Difficulty: 16 people, 39.02%

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 16 people, 39.02%
High Blood Pressure: 12 people, 29.27%
Multiple Myeloma (cancer of the plasma cells): 11 people, 26.83%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 24.39%
Mucosal Infection (infection of mucous membrane): 10 people, 24.39%
Cardiac Failure: 10 people, 24.39%
Gastritis (inflammation of stomach): 10 people, 24.39%
Gout (uric acid crystals building up in the body): 10 people, 24.39%
Hypertrophic Cardiomyopathy (a condition in which the heart muscle becomes abnormally thick): 10 people, 24.39%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 24.39%

* Approximation only. Some reports may have incomplete information.

Do you take Amoxicillin and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amoxicillin:

Amoxicillin (99,235 reports)

Browse all side effects of Amoxicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (365 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin (the active ingredients of Amoxicillin) and Amoxicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.