Amoxicillin and Compartment syndrome - a phase IV clinical study of FDA data

Summary:

Compartment syndrome is reported as a side effect among people who take Amoxicillin (amoxicillin), especially for people who are male, 20-29 old, have been taking the drug for 1 - 2 years also take Propecia, and have Androgenetic alopecia.

The phase IV clinical study analyzes which people have Compartment syndrome when taking Amoxicillin. It is created by eHealthMe based on reports of 95,831 people who have side effects when taking Amoxicillin from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Compartment syndrome?

Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels) is found to be associated with 295 drugs and 427 conditions by eHealthMe. Check the latest studies of Compartment syndrome.

On Aug, 08, 2026

95,831 people reported to have side effects when taking Amoxicillin.
Among them, 22 people (0.02%) have Compartment syndrome.

Could Amoxicillin cause Compartment syndrome?

Among these 22 people:

How long have people been on Amoxicillin when they have Compartment syndrome? *

What is the gender of people who have Compartment syndrome when taking Amoxicillin? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Compartment syndrome when taking Amoxicillin? *

What are other drugs people take besides Amoxicillin? *

What are other side effects people have besides Compartment syndrome? *

Visual Impairment: 15 people, 68.18%
Agitation (state of anxiety or nervous excitement): 15 people, 68.18%
Arrhythmias (irregular heartbeat): 15 people, 68.18%
Depression: 15 people, 68.18%
Cough: 15 people, 68.18%
Obstructive Airways Disorder (a progressive disease that makes it hard to breathe): 15 people, 68.18%
Papule: 13 people, 59.09%
Limb Injury: 13 people, 59.09%
Finger Deformity (a deformed position of the finger): 12 people, 54.55%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 12 people, 54.55%

What are the existing conditions these people have? *

Androgenetic Alopecia (common form of hair loss): 12 people, 54.55%
Hair Loss: 5 people, 22.73%
The Flu (the flu is caused by an influenza virus): 3 people, 13.64%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 9.09%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 4.55%
Labor Induction: 1 person, 4.55%
Infective Exacerbation Of Chronic Obstructive Airways Disease (severe infective lung disease with chronic obstructive airways disease): 1 person, 4.55%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 4.55%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 1 person, 4.55%
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Amoxicillin and have Compartment syndrome?

- Check whether Compartment syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amoxicillin:

Amoxicillin (99,235 reports)

Browse all side effects of Amoxicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Compartment syndrome:

Compartment syndrome (295 drugs)

Browse all the conditions that are associated with Compartment syndrome:

Compartment syndrome (427 conditions)

Related publications that referenced our studies

Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .
Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin (the active ingredients of Amoxicillin) and Amoxicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.