Anafranil and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Anafranil (clomipramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Celebrex, and have Fibromyalgia.

The phase IV clinical study analyzes which people have Sciatica when taking Anafranil. It is created by eHealthMe based on reports of 6,081 people who have side effects when taking Anafranil from the FDA, and is updated regularly.

What is Anafranil?

Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,149 drugs and 1,415 conditions by eHealthMe. Check the latest studies of Sciatica.

On Aug, 24, 2025

6,081 people reported to have side effects when taking Anafranil.
Among them, 18 people (0.3%) have Sciatica.

Among these 18 people:

How long have people been on Anafranil when they have Sciatica? *

What is the gender of people who have Sciatica when taking Anafranil? *

female: 93.75 %
male: 6.25 %

What is the age of people who have Sciatica when taking Anafranil? *

What are other drugs people take besides Anafranil? *

Celebrex: 12 people, 66.67%
Pantoprazole: 11 people, 61.11%
Diclofenac: 11 people, 61.11%
Magnesium: 11 people, 61.11%
Duspatal: 5 people, 27.78%
Prozac: 3 people, 16.67%
Lyrica: 3 people, 16.67%
Mirtazapine: 2 people, 11.11%
Tramadol Hydrochloride: 2 people, 11.11%
Ibuprofen: 2 people, 11.11%

What are other side effects people have besides Sciatica? *

Fatigue (feeling of tiredness): 14 people, 77.78%
Suicidal Ideation: 14 people, 77.78%
Personality Disorder: 14 people, 77.78%
Malaise (a feeling of general discomfort or uneasiness): 14 people, 77.78%
Joint Pain: 13 people, 72.22%
Back Pain: 13 people, 72.22%
Peripheral Swelling: 13 people, 72.22%
Weight Loss: 12 people, 66.67%
Gait Disturbance: 12 people, 66.67%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 12 people, 66.67%

What are the existing conditions these people have? *

Pain: 12 people, 66.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 66.67%
Myosclerosis (hardening of muscle tissue): 11 people, 61.11%
Neuralgia (pain in one or more nerves): 2 people, 11.11%
Joint Pain: 2 people, 11.11%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 5.56%
Osteoporosis (bones weak and more likely to break): 1 person, 5.56%
Hiv Infection: 1 person, 5.56%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 5.56%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Anafranil and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Anafranil:

Anafranil (6,304 reports)

Sciatica treatments and more:

Sciatica (28,503 reports)

Browse all side effects of Anafranil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,149 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,415 conditions)

Drugs similar to Anafranil and Sciatica :

How the study uses the data?

The study uses data from the FDA. It is based on clomipramine hydrochloride (the active ingredients of Anafranil) and Anafranil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.