Anafranil and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Anafranil (clomipramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Alprazolam, and have Diabetes.

The phase IV clinical study analyzes which people have Stroke when taking Anafranil. It is created by eHealthMe based on reports of 6,081 people who have side effects when taking Anafranil from the FDA, and is updated regularly.

What is Anafranil?

Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,358 drugs and 3,019 conditions by eHealthMe. Check the latest studies of Stroke.

On Feb, 14, 2026

6,081 people reported to have side effects when taking Anafranil.
Among them, 22 people (0.36%) have Stroke.

Among these 22 people:

How long have people been on Anafranil when they have Stroke? *

What is the gender of people who have Stroke when taking Anafranil? *

female: 68.18 %
male: 31.82 %

What is the age of people who have Stroke when taking Anafranil? *

What are other drugs people take besides Anafranil? *

Citalopram Hydrobromide: 4 people, 18.18%
Alprazolam: 4 people, 18.18%
Diazepam: 3 people, 13.64%
Dalmane: 3 people, 13.64%
Humira: 3 people, 13.64%
Simvastatin: 3 people, 13.64%
Atenolol: 3 people, 13.64%
Lipitor: 3 people, 13.64%
Sprycel: 2 people, 9.09%
Clonazepam: 2 people, 9.09%

What are other side effects people have besides Stroke? *

Pain: 4 people, 18.18%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 4 people, 18.18%
Memory Loss: 3 people, 13.64%
Acute Kidney Failure: 3 people, 13.64%
Common Peroneal Nerve Dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 3 people, 13.64%
Weight Decreased: 2 people, 9.09%
Emotional Distress: 2 people, 9.09%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 9.09%
Consciousness - Decreased: 2 people, 9.09%
General Physical Health Deterioration (weak health status): 2 people, 9.09%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 2 people, 9.09%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 9.09%
Diabetes: 2 people, 9.09%
Type 2 Diabetes: 1 person, 4.55%
Hypotension (abnormally low blood pressure): 1 person, 4.55%
Aneurysm Ruptured (expansion of the aneurysm reaches a point where the wall becomes too thin, the aneurysm will rupture): 1 person, 4.55%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 4.55%
Bipolar Disorder (mood disorder): 1 person, 4.55%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 1 person, 4.55%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Anafranil and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Anafranil:

Anafranil (6,304 reports)

Stroke treatments and more:

Stroke (334,633 reports)

Browse all side effects of Anafranil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,358 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,019 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on clomipramine hydrochloride (the active ingredients of Anafranil) and Anafranil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.