Aranesp and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Aranesp (darbepoetin alfa), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Norvasc, and have High blood pressure.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Aranesp. It is created by eHealthMe based on reports of 54,218 people who have side effects when taking Aranesp from the FDA, and is updated regularly.

What is Aranesp?

Aranesp has active ingredients of darbepoetin alfa. It is often used in anemia. eHealthMe is studying from 54,331 Aranesp users. Check the latest studies of Aranesp.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 948 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

54,218 people reported to have side effects when taking Aranesp.
Among them, 26 people (0.05%) have Knee joint replacement.

Could Aranesp cause Knee joint replacement?

Among these 26 people:

How long have people been on Aranesp when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Aranesp? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Knee joint replacement when taking Aranesp? *

What are other drugs people take besides Aranesp? *

What are other side effects people have besides Knee joint replacement? *

Infection: 6 people, 23.08%
Joint Injury: 6 people, 23.08%
Osteoporosis (bones weak and more likely to break): 6 people, 23.08%
Multiple Myeloma (cancer of the plasma cells): 6 people, 23.08%
Necrosis (the death of body tissue): 6 people, 23.08%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 6 people, 23.08%
Tooth Fracture: 5 people, 19.23%
Confusional State: 4 people, 15.38%
Allergic Rhinitis: 4 people, 15.38%
Blood Glucose Increased: 4 people, 15.38%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 26.92%
Plasmacytoma (neoplasm of plasma cells (usually in bone marrow)): 6 people, 23.08%
Anaemia (lack of blood): 5 people, 19.23%
Chronic Renal Failure (kidney failure): 4 people, 15.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 1 person, 3.85%
High Blood Cholesterol: 1 person, 3.85%
Hepatitis C: 1 person, 3.85%
Haemoglobin Decreased: 1 person, 3.85%
Diabetes: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Aranesp and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aranesp:

Aranesp (54,331 reports)

Browse all side effects of Aranesp:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (948 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on darbepoetin alfa (the active ingredients of Aranesp) and Aranesp (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.