Belsomra and Imuran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Belsomra (suvorexant) and Imuran (azathioprine). Common drug interactions include malaise among females and femoral neck fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Belsomra and Imuran. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Belsomra?

Belsomra has active ingredients of suvorexant. It is often used in insomnia. eHealthMe is studying from 12,961 Belsomra users. Check the latest studies of Belsomra.

What is Imuran?

Imuran has active ingredients of azathioprine. It is often used in crohn's disease. eHealthMe is studying from 34,915 Imuran users. Check the latest studies of Imuran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 21, 2026

12 people who take Belsomra and Imuran together, and have interactions are studied.

Belsomra and Imuran drug interactions.

What are the common drug interactions of Belsomra and Imuran, by gender? *:

female:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Platelet count decreased
  3. Pruritus (severe itching of the skin)
  4. Pyelonephritis (inflammation of kidney caused by bacteria)
  5. Wheezing (a high-pitched whistling sound made while you breath)
  6. Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
  7. Cardiac failure acute
  8. Cerebral haemorrhage (bleeding within the brain)
  9. Crying
  10. Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)

male:

  1. Femoral neck fracture (neck of femur bone fracture)

What are the common drug interactions of Belsomra and Imuran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
  2. Platelet count decreased
  3. Femoral neck fracture (neck of femur bone fracture)
  4. Cerebral haemorrhage (bleeding within the brain)

50-59:

n/a

60+:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
  3. Cardiac failure acute
  4. Crying
  5. Kidney infection
  6. Migraine (headache)
  7. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  8. Pyelonephritis (inflammation of kidney caused by bacteria)

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 33.33%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 25.00%
  3. Stress And Anxiety: 1 person, 8.33%
  4. Sleep Disorder: 1 person, 8.33%
  5. Periodontitis (inflammation of the tissue around the teeth): 1 person, 8.33%
  6. Liver Disorder (liver diseases): 1 person, 8.33%
  7. Indigestion: 1 person, 8.33%
  8. Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 1 person, 8.33%
  9. Depression: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Belsomra and Imuran?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Belsomra and Imuran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Belsomra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Imuran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Belsomra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Imuran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on suvorexant and azathioprine (the active ingredients of Belsomra and Imuran, respectively), and Belsomra and Imuran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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