Aricept and Frustration - a phase IV clinical study of FDA data

Summary:

Frustration is reported as a side effect among people who take Aricept (donepezil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Lexapro, and have Dementia alzheimer's type.

The phase IV clinical study analyzes which people have Frustration when taking Aricept. It is created by eHealthMe based on reports of 23,732 people who have side effects when taking Aricept from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Frustration?

Frustration (a form of poorly expressed anger) is found to be associated with 377 drugs and 623 conditions by eHealthMe. Check the latest studies of Frustration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

23,732 people reported to have side effects when taking Aricept.
Among them, 12 people (0.05%) have Frustration.

Among these 12 people:

How long have people been on Aricept when they have Frustration? *

What is the gender of people who have Frustration when taking Aricept? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Frustration when taking Aricept? *

What are other drugs people take besides Aricept? *

What are other side effects people have besides Frustration? *

Depression: 6 people, 50.00%
Confusional State: 5 people, 41.67%
Stress And Anxiety: 5 people, 41.67%
Headache (pain in head): 4 people, 33.33%
Muscle Spasms (muscle contraction): 4 people, 33.33%
Pain: 4 people, 33.33%
Feeling Abnormal: 4 people, 33.33%
Urinary Tract Infection: 4 people, 33.33%
Overdose: 3 people, 25.00%
Drug Ineffective: 3 people, 25.00%

What are the existing conditions these people have? *

Sedation: 3 people, 25.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 25.00%
Ill-Defined Disorder: 2 people, 16.67%
Head Injury: 2 people, 16.67%
Tumor: 1 person, 8.33%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 8.33%
Pain: 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
Neoplasm Malignant (cancer tumour): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Aricept and have Frustration?

- Check whether Frustration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aricept:

Aricept (24,756 reports)

Frustration treatments and more:

Frustration (4,545 reports)

Browse all side effects of Aricept:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Frustration:

Frustration (377 drugs)

Browse all the conditions that are associated with Frustration:

Frustration (623 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Aricept) and Aricept (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.