Artane and Anger - a phase IV clinical study of FDA data


Anger is found among people who take Artane, especially for people who are male, 30-39 old.

The phase IV clinical study analyzes which people take Artane and have Anger. It is created by eHealthMe based on reports of 3,350 people who have side effects when taking Artane from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Aug, 09, 2022

3,350 people reported to have side effects when taking Artane.
Among them, 33 people (0.99%) have Anger.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,348 Artane users for its effectiveness, alternative drugs and more.

What is Anger?

Anger is found to be associated with 2,094 drugs and 1,563 conditions by eHealthMe.

Number of Artane and Anger reports submitted per year:

Could Artane cause Anger?

Gender of people who have Anger when taking Artane *:

  • female: 39.39 %
  • male: 60.61 %

Age of people who have Anger when taking Artane *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.69 %
  • 30-39: 30.77 %
  • 40-49: 19.23 %
  • 50-59: 26.92 %
  • 60+: 15.38 %

Common drugs people take besides Artane *:

  1. Risperdal: 16 people, 48.48%
  2. Tegretol: 11 people, 33.33%
  3. Paxil: 9 people, 27.27%
  4. Zoloft: 9 people, 27.27%
  5. Valium: 9 people, 27.27%
  6. Levaquin: 8 people, 24.24%
  7. Seroquel: 7 people, 21.21%
  8. Ultram: 7 people, 21.21%
  9. Carbamazepine: 7 people, 21.21%
  10. Flomax: 7 people, 21.21%

Common side effects people have besides Anger *:

  1. Irritability: 14 people, 42.42%
  2. Hallucination, Auditory (perceiving sounds without auditory stimulus): 13 people, 39.39%
  3. Insomnia (sleeplessness): 13 people, 39.39%
  4. Depression: 13 people, 39.39%
  5. Loss Of Consciousness: 10 people, 30.30%
  6. Alanine Aminotransferase Increased: 10 people, 30.30%
  7. Suicidal Ideation: 10 people, 30.30%
  8. Stress And Anxiety: 10 people, 30.30%
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 27.27%
  10. Aggression: 9 people, 27.27%

Common conditions people have *:

  1. Pain: 8 people, 24.24%
  2. Stress And Anxiety: 5 people, 15.15%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 15.15%
  4. Bipolar Disorder (mood disorder): 4 people, 12.12%
  5. High Blood Cholesterol: 2 people, 6.06%
  6. Quit Smoking: 2 people, 6.06%
  7. Depression: 2 people, 6.06%
  8. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 1 person, 3.03%
  9. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.03%
  10. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Artane and have Anger?

Check whether Anger is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Artane:

Anger treatments and more:

COVID vaccines that are related to Anger:

How severe was Anger and when was it recovered:

Expand to all the drugs that have ingredients of trihexyphenidyl hydrochloride:

Common drugs associated with Anger:

All the drugs that are associated with Anger:

Common conditions associated with Anger:

All the conditions that are associated with Anger:

  • Anger (1,563 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trihexyphenidyl hydrochloride (the active ingredients of Artane) and Artane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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