Arthrotec and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Arthrotec (diclofenac sodium; misoprostol), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Frova, and have Agitation.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Arthrotec. It is created by eHealthMe based on reports of 11,570 people who have side effects when taking Arthrotec from the FDA, and is updated regularly.

What is Arthrotec?

Arthrotec has active ingredients of diclofenac sodium; misoprostol. It is often used in arthritis. eHealthMe is studying from 11,986 Arthrotec users. Check the latest studies of Arthrotec.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,087 drugs and 1,361 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 12, 2026

11,570 people reported to have side effects when taking Arthrotec.
Among them, 22 people (0.19%) have Multiple sclerosis.

Could Arthrotec cause Multiple sclerosis?

Among these 22 people:

How long have people been on Arthrotec when they have Multiple sclerosis? *

What is the gender of people who have Multiple sclerosis when taking Arthrotec? *

female: 77.27 %
male: 22.73 %

What is the age of people who have Multiple sclerosis when taking Arthrotec? *

What are other drugs people take besides Arthrotec? *

What are other side effects people have besides Multiple sclerosis? *

Headache (pain in head): 12 people, 54.55%
Depression: 10 people, 45.45%
Renal Impairment (severely reduced kidney function): 9 people, 40.91%
Road Traffic Accident: 9 people, 40.91%
Intervertebral Disc Protrusion (spinal disc protrusion): 9 people, 40.91%
Type 2 Diabetes: 9 people, 40.91%
Weakness: 8 people, 36.36%
Fatigue (feeling of tiredness): 8 people, 36.36%
Gastric Ulcer Haemorrhage (bleeding ulcer of stomach): 8 people, 36.36%
Migraine (headache): 7 people, 31.82%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 18.18%
Oedema Peripheral (superficial swelling): 4 people, 18.18%
Migraine (headache): 4 people, 18.18%
High Blood Pressure: 4 people, 18.18%
Headache (pain in head): 4 people, 18.18%
Gout (uric acid crystals building up in the body): 4 people, 18.18%
Back Pain: 4 people, 18.18%
Arrhythmias (irregular heartbeat): 4 people, 18.18%
Agitation (state of anxiety or nervous excitement): 4 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Arthrotec and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arthrotec:

Arthrotec (11,986 reports)

Multiple sclerosis treatments and more:

Multiple sclerosis (799,636 reports)

How severe was Multiple sclerosis and when was it recovered:

Multiple sclerosis in Arthrotec

Expand to all the drugs that have ingredients of diclofenac sodium; misoprostol:

Multiple sclerosis and drugs with ingredients of diclofenac sodium; misoprostol (20 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Arthrotec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,087 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,361 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium; misoprostol (the active ingredients of Arthrotec) and Arthrotec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.