Augmentin and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Augmentin (amoxicillin; clavulanate potassium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Flagyl, and have Multiple myeloma.

The phase IV clinical study analyzes which people have C. diff when taking Augmentin. It is created by eHealthMe based on reports of 41,293 people who have side effects when taking Augmentin from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is C. diff?

C. diff is found to be associated with 1,640 drugs and 1,768 conditions by eHealthMe. Check the latest studies of C. diff.

On Aug, 23, 2025

41,293 people reported to have side effects when taking Augmentin.
Among them, 228 people (0.55%) have C. diff.

Among these 228 people:

How long have people been on Augmentin when they have C. diff? *

What is the gender of people who have C. diff when taking Augmentin? *

female: 68.81 %
male: 31.19 %

What is the age of people who have C. diff when taking Augmentin? *

What are other drugs people take besides Augmentin? *

What are other side effects people have besides C. diff? *

Diarrhea: 58 people, 25.44%
Abdominal Pain: 35 people, 15.35%
Acute Kidney Failure: 35 people, 15.35%
Pneumonia: 31 people, 13.60%
Anaemia (lack of blood): 31 people, 13.60%
Osteomyelitis (infection of bone): 30 people, 13.16%
Weakness: 30 people, 13.16%
Fever: 26 people, 11.40%
Dyspnea (difficult or laboured breathing): 24 people, 10.53%
Back Pain: 24 people, 10.53%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 25 people, 10.96%
High Blood Pressure: 24 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 7.89%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 18 people, 7.89%
Pneumonia: 18 people, 7.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 7.02%
Fever: 15 people, 6.58%
Pain: 14 people, 6.14%
Stress And Anxiety: 13 people, 5.70%
Osteoporosis (bones weak and more likely to break): 11 people, 4.82%

* Approximation only. Some reports may have incomplete information.

Do you take Augmentin and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Augmentin:

Augmentin (42,620 reports)

C. diff treatments and more:

C. diff (13,844 reports)

How severe was C. diff and when was it recovered:

C. diff in Augmentin

Expand to all the drugs that have ingredients of amoxicillin; clavulanate potassium:

C. diff and drugs with ingredients of amoxicillin; clavulanate potassium (332 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Augmentin side effects:

Augmentin side effect: Dyspnea (difficult or laboured breathing) (2,578 reports)
Augmentin side effect: Pneumonia (2,277 reports)

Browse all side effects of Augmentin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with C. diff:

Browse all the drugs that are associated with C. diff:

C. diff (1,640 drugs)

Common conditions associated with C. diff:

Malignant plasmacytoma: 814 reports
High blood pressure: 750 reports
Acute lymphoblastic anemia: 516 reports
Alternative medicine - pain relief: 482 reports
Crohn's disease: 454 reports
Urinary tract infection: 411 reports
Ms hug: 348 reports
Ulcerative colitis: 343 reports
Ra: 332 reports
Osteoporosis: 322 reports

Browse all the conditions that are associated with C. diff:

C. diff (1,768 conditions)

Drugs similar to Augmentin and C. diff :

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin; clavulanate potassium (the active ingredients of Augmentin) and Augmentin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.