Avalide and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Avalide (hydrochlorothiazide; irbesartan), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Xanax, and have Diabetes.

The phase IV clinical study analyzes which people have Depression when taking Avalide. It is created by eHealthMe based on reports of 5,642 people who have side effects when taking Avalide from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Depression?

Depression is found to be associated with 3,202 drugs and 4,116 conditions by eHealthMe. Check the latest studies of Depression.

On Jan, 28, 2026

5,642 people reported to have side effects when taking Avalide.
Among them, 179 people (3.17%) have Depression.

Among these 179 people:

* Approximation only. Some reports may have incomplete information.

Do you take Avalide and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avalide:

Avalide (5,943 reports)

Depression treatments and more:

Depression (652,117 reports)

How severe was Depression and when was it recovered:

Depression in Avalide

Expand to all the drugs that have ingredients of hydrochlorothiazide; irbesartan:

Depression and drugs with ingredients of hydrochlorothiazide; irbesartan

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Avalide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,202 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,116 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; irbesartan (the active ingredients of Avalide) and Avalide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.