Avalide and Hypertensive crisis - a phase IV clinical study of FDA data

Summary:

Hypertensive crisis is reported as a side effect among people who take Avalide (hydrochlorothiazide; irbesartan), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Vioxx, and have Oedema peripheral.

The phase IV clinical study analyzes which people have Hypertensive crisis when taking Avalide. It is created by eHealthMe based on reports of 5,642 people who have side effects when taking Avalide from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Hypertensive crisis?

Hypertensive crisis is found to be associated with 783 drugs and 932 conditions by eHealthMe. Check the latest studies of Hypertensive crisis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

5,642 people reported to have side effects when taking Avalide.
Among them, 11 people (0.19%) have Hypertensive crisis.

Could Avalide cause Hypertensive crisis?

Among these 11 people:

How long have people been on Avalide when they have Hypertensive crisis? *

What is the gender of people who have Hypertensive crisis when taking Avalide? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Hypertensive crisis when taking Avalide? *

What are other drugs people take besides Avalide? *

What are other side effects people have besides Hypertensive crisis? *

Chest Pain: 5 people, 45.45%
Heart Attack: 4 people, 36.36%
Atherosclerosis (disorder of the arteries): 4 people, 36.36%
Feeling Abnormal: 4 people, 36.36%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 4 people, 36.36%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 36.36%
Bradycardia (abnormally slow heart action): 4 people, 36.36%
Cardiac Failure: 4 people, 36.36%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 27.27%
Joint Dislocation (a joint position is changed from normal position): 3 people, 27.27%

What are the existing conditions these people have? *

Pain: 4 people, 36.36%
Oedema Peripheral (superficial swelling): 4 people, 36.36%
Inflammation: 3 people, 27.27%
Tendonitis (a condition that causes pain and swelling of tendons): 2 people, 18.18%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Type 2 Diabetes: 1 person, 9.09%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 1 person, 9.09%
Back Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Avalide and have Hypertensive crisis?

- Check whether Hypertensive crisis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avalide:

Avalide (5,943 reports)

Hypertensive crisis treatments and more:

Hypertensive crisis (14,151 reports)

How severe was Hypertensive crisis and when was it recovered:

Hypertensive crisis in Avalide

Expand to all the drugs that have ingredients of hydrochlorothiazide; irbesartan:

Hypertensive crisis and drugs with ingredients of hydrochlorothiazide; irbesartan

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Avalide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertensive crisis:

Hypertensive crisis (783 drugs)

Browse all the conditions that are associated with Hypertensive crisis:

Hypertensive crisis (932 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; irbesartan (the active ingredients of Avalide) and Avalide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.