Avandia and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Avandia (rosiglitazone maleate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Prilosec, and have Osteoporosis.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Avandia. It is created by eHealthMe based on reports of 141,991 people who have side effects when taking Avandia from the FDA, and is updated regularly.

What is Avandia?

Avandia has active ingredients of rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 142,155 Avandia users. Check the latest studies of Avandia.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 495 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jul, 14, 2026

141,991 people reported to have side effects when taking Avandia.
Among them, 19 people (0.01%) have Systemic sclerosis (scleroderma).

Could Avandia cause Systemic sclerosis (scleroderma)?

Among these 19 people:

How long have people been on Avandia when they have Systemic sclerosis (scleroderma)? *

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Avandia? *

female: 68.42 %
male: 31.58 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Avandia? *

What are other drugs people take besides Avandia? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Oedema Peripheral (superficial swelling): 12 people, 63.16%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 57.89%
Acute Kidney Failure: 11 people, 57.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 57.89%
Asthma: 11 people, 57.89%
Pneumonia: 11 people, 57.89%
Lung Disorder (lung disease): 11 people, 57.89%
Gums - Swollen: 11 people, 57.89%
Pain: 11 people, 57.89%
Sinusitis (inflammation of sinus): 11 people, 57.89%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 57.89%
Thrombocytopenia (decrease of platelets in blood): 10 people, 52.63%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 10 people, 52.63%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 10.53%
Pain: 1 person, 5.26%
High Blood Cholesterol: 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
Gastritis (inflammation of stomach): 1 person, 5.26%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 5.26%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Avandia and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avandia:

Avandia (142,155 reports)

Browse all side effects of Avandia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (495 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rosiglitazone maleate (the active ingredients of Avandia) and Avandia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.