Aygestin and Mood swings - a phase IV clinical study of FDA data

Summary:

Mood swings is reported as a side effect among people who take Aygestin (norethindrone acetate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Lupron Depot, and have Pain.

The phase IV clinical study analyzes which people have Mood swings when taking Aygestin. It is created by eHealthMe based on reports of 1,047 people who have side effects when taking Aygestin from the FDA, and is updated regularly.

What is Aygestin?

Aygestin has active ingredients of norethindrone acetate. It is often used in endometriosis. eHealthMe is studying from 1,107 Aygestin users. Check the latest studies of Aygestin.

What is Mood swings?

Mood swings (an extreme or rapid change in mood) is found to be associated with 1,670 drugs and 2,129 conditions by eHealthMe. Check the latest studies of Mood swings.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

1,047 people reported to have side effects when taking Aygestin.
Among them, 22 people (2.1%) have Mood swings.

Among these 22 people:

How long have people been on Aygestin when they have Mood swings? *

What is the gender of people who have Mood swings when taking Aygestin? *

female: 100 %
male: 0.0 %

What is the age of people who have Mood swings when taking Aygestin? *

What are other drugs people take besides Aygestin? *

What are other side effects people have besides Mood swings? *

Hot Flush (sudden feelings of heat): 8 people, 36.36%
Pelvic Pain: 5 people, 22.73%
Weight Increased: 4 people, 18.18%
Insomnia (sleeplessness): 4 people, 18.18%
Nausea (feeling of having an urge to vomit): 4 people, 18.18%
Emotional Disorder: 4 people, 18.18%
Memory Loss: 4 people, 18.18%
Night Sweats (sweating in night): 3 people, 13.64%
Vaginal Bleeding Between Periods: 3 people, 13.64%
Migraine (headache): 3 people, 13.64%

What are the existing conditions these people have? *

Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 5 people, 22.73%
Pain: 5 people, 22.73%
Stress And Anxiety: 3 people, 13.64%
Anaemia (lack of blood): 3 people, 13.64%
Depression: 2 people, 9.09%
Panic Disorder: 1 person, 4.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.55%
Migraine (headache): 1 person, 4.55%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.55%
High Blood Pressure: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Aygestin and have Mood swings?

- Check whether Mood swings is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aygestin:

Aygestin (1,107 reports)

Mood swings treatments and more:

Mood swings (74,716 reports)

Browse all side effects of Aygestin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mood swings:

Mood swings (1,670 drugs)

Browse all the conditions that are associated with Mood swings:

Mood swings (2,129 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on norethindrone acetate (the active ingredients of Aygestin) and Aygestin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.