Azathioprine and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Azathioprine (azathioprine sodium), especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Azathioprine. It is created by eHealthMe based on reports of 59,932 people who have side effects when taking Azathioprine from the FDA, and is updated regularly.

What is Azathioprine?

Azathioprine has active ingredients of azathioprine sodium. It is often used in crohn's disease. eHealthMe is studying from 60,623 Azathioprine users. Check the latest studies of Azathioprine.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

59,932 people reported to have side effects when taking Azathioprine.
Among them, 71 people (0.12%) have Knee joint replacement.

Could Azathioprine cause Knee joint replacement?

Among these 71 people:

How long have people been on Azathioprine when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Azathioprine? *

female: 70.97 %
male: 29.03 %

What is the age of people who have Knee joint replacement when taking Azathioprine? *

What are other drugs people take besides Azathioprine? *

What are other side effects people have besides Knee joint replacement? *

Type 2 Diabetes: 48 people, 67.61%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 45 people, 63.38%
Joint Pain: 44 people, 61.97%
High Blood Cholesterol: 42 people, 59.15%
High Blood Pressure: 41 people, 57.75%
Rashes (redness): 40 people, 56.34%
Abdominal Discomfort: 38 people, 53.52%
Drug Ineffective: 38 people, 53.52%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 37 people, 52.11%
Infusion Related Reaction: 37 people, 52.11%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 55 people, 77.46%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 27 people, 38.03%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 17 people, 23.94%
Psoriasis (immune-mediated disease that affects the skin): 16 people, 22.54%
Fibromyalgia (a long-term condition which causes pain all over the body): 13 people, 18.31%
Headache (pain in head): 11 people, 15.49%
Indigestion: 11 people, 15.49%
Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 8.45%
Pain: 6 people, 8.45%
Migraine (headache): 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

Do you take Azathioprine and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Azathioprine:

Azathioprine (60,623 reports)

Browse all side effects of Azathioprine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on azathioprine sodium (the active ingredients of Azathioprine) and Azathioprine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.