Bactrim and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Bactrim (sulfamethoxazole; trimethoprim), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Paxil, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Flat affect when taking Bactrim. It is created by eHealthMe based on reports of 86,509 people who have side effects when taking Bactrim from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 291 drugs and 459 conditions by eHealthMe. Check the latest studies of Flat affect.

On Jul, 08, 2026

86,509 people reported to have side effects when taking Bactrim.
Among them, 19 people (0.02%) have Flat affect.

Among these 19 people:

How long have people been on Bactrim when they have Flat affect? *

What is the gender of people who have Flat affect when taking Bactrim? *

female: 72.22 %
male: 27.78 %

What is the age of people who have Flat affect when taking Bactrim? *

What are other drugs people take besides Bactrim? *

What are other side effects people have besides Flat affect? *

Depression: 12 people, 63.16%
Insomnia (sleeplessness): 11 people, 57.89%
Stress And Anxiety: 10 people, 52.63%
Tremor (trembling or shaking movements in one or more parts of your body): 10 people, 52.63%
Suicidal Ideation: 9 people, 47.37%
Fall: 8 people, 42.11%
Nausea (feeling of having an urge to vomit): 7 people, 36.84%
Headache (pain in head): 7 people, 36.84%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 6 people, 31.58%
Fatigue (feeling of tiredness): 6 people, 31.58%

What are the existing conditions these people have? *

Depression: 3 people, 15.79%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
Tonic Clonic Movements (generalized seizure that affects the entire brain): 1 person, 5.26%
Anaemia (lack of blood): 1 person, 5.26%
Aspergillosis (an infection caused by a fungus called aspergillus): 1 person, 5.26%
Asthma: 1 person, 5.26%
Bipolar Disorder (mood disorder): 1 person, 5.26%
Cardiac Failure: 1 person, 5.26%
Chronic Graft Versus Host Disease In Skin (damage by immune cells to skin after grafting): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Flat affect?

- Check whether Flat affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bactrim:

Bactrim (89,117 reports)

Flat affect treatments and more:

Flat affect (2,784 reports)

How severe was Flat affect and when was it recovered:

Flat affect in Bactrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Flat affect and drugs with ingredients of sulfamethoxazole; trimethoprim

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Flat affect (291 drugs)

Browse all the conditions that are associated with Flat affect:

Flat affect (459 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.