Bactrim and Sinus bradycardia - a phase IV clinical study of FDA data

Summary:

Sinus bradycardia is reported as a side effect among people who take Bactrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Hydrochlorothiazide, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Sinus bradycardia when taking Bactrim. It is created by eHealthMe based on reports of 86,509 people who have side effects when taking Bactrim from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Sinus bradycardia?

Sinus bradycardia (an unusually slow heartbeat due to heart disease) is found to be associated with 898 drugs and 1,055 conditions by eHealthMe. Check the latest studies of Sinus bradycardia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

86,509 people reported to have side effects when taking Bactrim.
Among them, 80 people (0.09%) have Sinus bradycardia.

Among these 80 people:

How long have people been on Bactrim when they have Sinus bradycardia? *

What is the gender of people who have Sinus bradycardia when taking Bactrim? *

female: 48.68 %
male: 51.32 %

What is the age of people who have Sinus bradycardia when taking Bactrim? *

What are other drugs people take besides Bactrim? *

What are other side effects people have besides Sinus bradycardia? *

Hypotension (abnormally low blood pressure): 27 people, 33.75%
Fatigue (feeling of tiredness): 25 people, 31.25%
Diarrhea: 23 people, 28.75%
Fever: 21 people, 26.25%
Chills (felling of cold): 20 people, 25.00%
Hyperkalemia (damage to or disease of the kidney): 20 people, 25.00%
Muscle Aches (muscle pain): 18 people, 22.50%
Malaise (a feeling of general discomfort or uneasiness): 18 people, 22.50%
Nausea (feeling of having an urge to vomit): 18 people, 22.50%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 18 people, 22.50%

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 18 people, 22.50%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 14 people, 17.50%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 14 people, 17.50%
Diabetes: 14 people, 17.50%
Multiple Myeloma (cancer of the plasma cells): 14 people, 17.50%
Herpes Zoster: 9 people, 11.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 8.75%
High Blood Pressure: 7 people, 8.75%
Breast Cancer: 5 people, 6.25%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Sinus bradycardia?

- Check whether Sinus bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bactrim:

Bactrim (89,117 reports)

Sinus bradycardia treatments and more:

Sinus bradycardia (12,848 reports)

How severe was Sinus bradycardia and when was it recovered:

Sinus bradycardia in Bactrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Sinus bradycardia and drugs with ingredients of sulfamethoxazole; trimethoprim (171 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus bradycardia:

Sinus bradycardia (898 drugs)

Browse all the conditions that are associated with Sinus bradycardia:

Sinus bradycardia (1,055 conditions)

Related publications that referenced our studies

Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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