Benadryl and Cachexia - a phase IV clinical study of FDA data

Summary:

Cachexia is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Cachexia when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,949 Benadryl users. Check the latest studies of Benadryl.

What is Cachexia?

Cachexia (loss of weight) is found to be associated with 710 drugs and 1,194 conditions by eHealthMe. Check the latest studies of Cachexia.

On Dec, 22, 2025

100,139 people reported to have side effects when taking Benadryl.
Among them, 80 people (0.08%) have Cachexia.

Among these 80 people:

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Cachexia?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,949 reports)

Cachexia treatments and more:

Cachexia (7,763 reports)

How severe was Cachexia and when was it recovered:

Cachexia in Benadryl

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Cachexia and drugs with ingredients of diphenhydramine hydrochloride (105 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Benadryl side effects:

Benadryl side effect: Rashes (redness) (10,643 reports)
Benadryl side effect: Itching (8,437 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Cachexia:

Browse all the drugs that are associated with Cachexia:

Cachexia (710 drugs)

Common conditions associated with Cachexia:

Hiv infection: 326 reports
Human immunodeficiency virus infection: 320 reports
Hiv test: 302 reports
Pain exacerbated: 296 reports
Alternative medicine - pain relief: 283 reports
Hypertension aggravated: 218 reports
Blood pressure increased: 212 reports
Metastatic renal cell carcinoma: 196 reports
Acupuncture and pain: 193 reports
Ra: 177 reports

Browse all the conditions that are associated with Cachexia:

Cachexia (1,194 conditions)

Drugs similar to Benadryl and Cachexia :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.