Benadryl and Dermatitis psoriasiform - a phase IV clinical study of FDA data

Summary:

Dermatitis psoriasiform is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Inflectra, and have Crohn's disease.

The phase IV clinical study analyzes which people have Dermatitis psoriasiform when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Dermatitis psoriasiform?

Dermatitis psoriasiform (large white or silver flakes on the skin) is found to be associated with 189 drugs and 277 conditions by eHealthMe. Check the latest studies of Dermatitis psoriasiform.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 36 people (0.04%) have Dermatitis psoriasiform.

Could Benadryl cause Dermatitis psoriasiform?

Among these 36 people:

How long have people been on Benadryl when they have Dermatitis psoriasiform? *

What is the gender of people who have Dermatitis psoriasiform when taking Benadryl? *

female: 75 %
male: 25 %

What is the age of people who have Dermatitis psoriasiform when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Dermatitis psoriasiform? *

Joint Pain: 25 people, 69.44%
Nausea And Vomiting: 16 people, 44.44%
Oropharyngeal Pain: 16 people, 44.44%
Hair Loss: 16 people, 44.44%
Nasopharyngitis (inflammation of the nasopharynx): 15 people, 41.67%
Urinary Tract Infection: 15 people, 41.67%
Fatigue (feeling of tiredness): 15 people, 41.67%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 15 people, 41.67%
Wound Infection: 14 people, 38.89%
Sputum Discolored: 14 people, 38.89%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 25 people, 69.44%
Psoriasis (immune-mediated disease that affects the skin): 10 people, 27.78%
High Blood Pressure: 7 people, 19.44%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 13.89%
Rash Pustular (redness with pustules): 5 people, 13.89%
Pain In Extremity: 5 people, 13.89%
Cardiac Failure: 5 people, 13.89%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 13.89%
Bladder Transitional Cell Carcinoma (types of bladder cancer): 5 people, 13.89%
Indigestion: 5 people, 13.89%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Dermatitis psoriasiform?

- Check whether Dermatitis psoriasiform is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,955 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dermatitis psoriasiform:

Dermatitis psoriasiform (189 drugs)

Browse all the conditions that are associated with Dermatitis psoriasiform:

Dermatitis psoriasiform (277 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.