Benadryl and Iron overload - a phase IV clinical study of FDA data

Summary:

Iron overload is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 10-19 old, also take Tylenol, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Iron overload when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,949 Benadryl users. Check the latest studies of Benadryl.

What is Iron overload?

Iron overload is found to be associated with 245 drugs and 310 conditions by eHealthMe. Check the latest studies of Iron overload.

On Dec, 22, 2025

100,139 people reported to have side effects when taking Benadryl.
Among them, 21 people (0.02%) have Iron overload.

Among these 21 people:

What is the gender of people who have Iron overload when taking Benadryl? *

female: 52.94 %
male: 47.06 %

What is the age of people who have Iron overload when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Iron overload? *

Fatigue (feeling of tiredness): 11 people, 52.38%
Dyspnea (difficult or laboured breathing): 10 people, 47.62%
Diarrhea: 9 people, 42.86%
Abdominal Pain: 9 people, 42.86%
Chest Pain: 9 people, 42.86%
Headache (pain in head): 9 people, 42.86%
Fever: 9 people, 42.86%
Pneumonia: 8 people, 38.10%
Cough: 7 people, 33.33%
Atelectasis (partial or complete collapse of the lung): 7 people, 33.33%

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 7 people, 33.33%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 23.81%
Pain: 4 people, 19.05%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 14.29%
Aplastic Anemia: 3 people, 14.29%
Stress And Anxiety: 2 people, 9.52%
Nausea And Vomiting: 2 people, 9.52%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Cough: 2 people, 9.52%
Anaemia (lack of blood): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Iron overload?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,949 reports)

Iron overload treatments and more:

Iron overload (10,704 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Iron overload:

Iron overload (245 drugs)

Browse all the conditions that are associated with Iron overload:

Iron overload (310 conditions)

Drugs similar to Benadryl and Iron overload :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.