Benadryl and Macular hole - a phase IV clinical study of FDA data

Summary:

Macular hole is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are male, 60+ old, also take Ranitidine, and have High blood pressure.

The phase IV clinical study analyzes which people have Macular hole when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Macular hole?

Macular hole (small break in the macula, the central area of the retina) is found to be associated with 176 drugs and 529 conditions by eHealthMe. Check the latest studies of Macular hole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 18 people (0.02%) have Macular hole.

Among these 18 people:

What is the gender of people who have Macular hole when taking Benadryl? *

female: 11.11 %
male: 88.89 %

What is the age of people who have Macular hole when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Macular hole? *

High Blood Cholesterol: 17 people, 94.44%
Wound Dehiscence (a surgical incision reopens either internally or externally): 16 people, 88.89%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 16 people, 88.89%
Muscle Spasms (muscle contraction): 16 people, 88.89%
Muscle Aches (muscle pain): 16 people, 88.89%
Multiple Myeloma (cancer of the plasma cells): 16 people, 88.89%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 16 people, 88.89%
Constipation: 16 people, 88.89%
Loose Tooth: 16 people, 88.89%
Cough: 16 people, 88.89%

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 94.44%
Joint Pain: 16 people, 88.89%
Blood Triglycerides Decreased: 16 people, 88.89%
Diarrhea: 16 people, 88.89%
Fluid Retention (an abnormal accumulation of fluid in the blood): 16 people, 88.89%
High Blood Cholesterol: 16 people, 88.89%
Seasonal Allergy (allergic condition due to certain season): 16 people, 88.89%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 16 people, 88.89%
Mood Swings (an extreme or rapid change in mood): 16 people, 88.89%
Multiple Myeloma (cancer of the plasma cells): 16 people, 88.89%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Macular hole?

- Check whether Macular hole is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,956 reports)

Macular hole treatments and more:

Macular hole (1,673 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macular hole:

Macular hole (176 drugs)

Browse all the conditions that are associated with Macular hole:

Macular hole (529 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.