Benadryl and Malabsorption - a phase IV clinical study of FDA data

Summary:

Malabsorption is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zofran, and have Colon cancer metastatic.

The phase IV clinical study analyzes which people have Malabsorption when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,949 Benadryl users. Check the latest studies of Benadryl.

What is Malabsorption?

Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract) is found to be associated with 700 drugs and 1,090 conditions by eHealthMe. Check the latest studies of Malabsorption.

On Jan, 17, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 66 people (0.07%) have Malabsorption.

Among these 66 people:

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Malabsorption?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,949 reports)

Malabsorption treatments and more:

Malabsorption (8,910 reports)

How severe was Malabsorption and when was it recovered:

Malabsorption in Benadryl

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Malabsorption and drugs with ingredients of diphenhydramine hydrochloride (114 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Benadryl side effects:

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Malabsorption:

Browse all the drugs that are associated with Malabsorption:

Malabsorption (700 drugs)

Common conditions associated with Malabsorption:

Hypertension: 2,367 reports
Crohn's disease: 330 reports
Pain exacerbated: 250 reports
Alternative medicine - pain relief: 248 reports
Gastro-oesophageal reflux disease: 234 reports
High blood cholesterol and triglycerides: 220 reports
Depression: 216 reports
Acupuncture and pain: 201 reports
Diabetes mellitus: 193 reports
Diabetes: 190 reports

Browse all the conditions that are associated with Malabsorption:

Malabsorption (1,090 conditions)

Drugs similar to Benadryl and Malabsorption :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.