Benadryl and Progressive multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Progressive multiple sclerosis is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, also take Ocrevus, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Progressive multiple sclerosis when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Progressive multiple sclerosis?

Progressive multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord) is found to be associated with 102 drugs and 114 conditions by eHealthMe. Check the latest studies of Progressive multiple sclerosis.

On Aug, 11, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 16 people (0.02%) have Progressive multiple sclerosis.

Could Benadryl cause Progressive multiple sclerosis?

Among these 16 people:

What is the gender of people who have Progressive multiple sclerosis when taking Benadryl? *

female: 93.33 %
male: 6.67 %

What is the age of people who have Progressive multiple sclerosis when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Progressive multiple sclerosis? *

Fatigue (feeling of tiredness): 7 people, 43.75%
Urticaria (rash of round, red welts on the skin that itch intensely): 6 people, 37.50%
Weakness: 6 people, 37.50%
Fall: 6 people, 37.50%
Memory Loss: 5 people, 31.25%
Dyspnea (difficult or laboured breathing): 5 people, 31.25%
Stress And Anxiety: 4 people, 25.00%
Dry Mouth: 4 people, 25.00%
Dysstasia (difficulty in standing): 4 people, 25.00%
Nausea (feeling of having an urge to vomit): 4 people, 25.00%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 68.75%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 43.75%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 37.50%
Pain: 6 people, 37.50%
Stress And Anxiety: 5 people, 31.25%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 18.75%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 3 people, 18.75%
Headache (pain in head): 3 people, 18.75%
Constipation: 2 people, 12.50%
Sleep Disorder: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Progressive multiple sclerosis?

- Check whether Progressive multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,955 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Progressive multiple sclerosis:

Progressive multiple sclerosis (102 drugs)

Browse all the conditions that are associated with Progressive multiple sclerosis:

Progressive multiple sclerosis (114 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.