Benadryl and Skin erosion - a phase IV clinical study of FDA data

Summary:

Skin erosion is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 40-49 old, also take Vitamin C, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Skin erosion when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Skin erosion?

Skin erosion (a discontinuity of the skin) is found to be associated with 360 drugs and 527 conditions by eHealthMe. Check the latest studies of Skin erosion.

On Jul, 14, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 36 people (0.04%) have Skin erosion.

Among these 36 people:

What is the gender of people who have Skin erosion when taking Benadryl? *

female: 95 %
male: 5 %

What is the age of people who have Skin erosion when taking Benadryl? *

What are other drugs people take besides Benadryl? *

Vitamin C: 26 people, 72.22%
Calcium: 25 people, 69.44%
Tylenol: 25 people, 69.44%
Oxycontin: 24 people, 66.67%
Gabapentin: 17 people, 47.22%
Dexamethasone: 17 people, 47.22%
Lorazepam: 17 people, 47.22%
Methylprednisolone Sodium Succinate: 16 people, 44.44%
Lupron: 16 people, 44.44%
Oregano: 15 people, 41.67%

What are other side effects people have besides Skin erosion? *

Infusion Related Reaction: 17 people, 47.22%
Respiratory Disorder (respiratory disease): 17 people, 47.22%
Blood Pressure Diastolic Abnormal: 17 people, 47.22%
Blood Pressure Diastolic Increased: 17 people, 47.22%
Blood Pressure Systolic Increased: 17 people, 47.22%
Drug Intolerance (drug sensitivity): 17 people, 47.22%
Fatigue (feeling of tiredness): 17 people, 47.22%
Gastric Disorder (disease of stomach): 17 people, 47.22%
Heart Rate Increased: 17 people, 47.22%
Headache (pain in head): 16 people, 44.44%

What are the existing conditions these people have? *

Vasculitis (inflammation of a blood vessel or blood vessels): 24 people, 66.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 24 people, 66.67%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 11.11%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 3 people, 8.33%
Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 5.56%
Rosacea (a skin condition that causes facial redness): 1 person, 2.78%
Localised Infection (infection at the single location): 1 person, 2.78%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 2.78%
Acne (skin problems that cause pimples): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Skin erosion?

- Check whether Skin erosion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Skin erosion treatments and more:

Skin erosion (3,354 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin erosion:

Skin erosion (360 drugs)

Browse all the conditions that are associated with Skin erosion:

Skin erosion (527 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.