Benadryl and Urine output increased - a phase IV clinical study of FDA data

Summary:

Urine output increased is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Aspirin, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Urine output increased when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Urine output increased?

Urine output increased is found to be associated with 310 drugs and 573 conditions by eHealthMe. Check the latest studies of Urine output increased.

On Jul, 16, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 25 people (0.02%) have Urine output increased.

Could Benadryl cause Urine output increased?

Among these 25 people:

How long have people been on Benadryl when they have Urine output increased? *

What is the gender of people who have Urine output increased when taking Benadryl? *

female: 84 %
male: 16 %

What is the age of people who have Urine output increased when taking Benadryl? *

What are other drugs people take besides Benadryl? *

Aspirin: 11 people, 44.00%
Folic Acid: 10 people, 40.00%
Hydrocodone Bitartrate And Acetaminophen: 9 people, 36.00%
Glucosamine Sulfate: 9 people, 36.00%
Lactulose: 9 people, 36.00%
Amitiza: 9 people, 36.00%
Skelaxin: 9 people, 36.00%
Reclast: 9 people, 36.00%
Omeprazole: 9 people, 36.00%
Desowen: 9 people, 36.00%

What are other side effects people have besides Urine output increased? *

Pain: 13 people, 52.00%
Nausea (feeling of having an urge to vomit): 13 people, 52.00%
Confusional State: 12 people, 48.00%
Urinary Tract Infection: 12 people, 48.00%
Urination - Painful: 11 people, 44.00%
Fall: 11 people, 44.00%
Constipation: 11 people, 44.00%
Stress And Anxiety: 10 people, 40.00%
Nausea And Vomiting: 10 people, 40.00%
Nervousness: 10 people, 40.00%

What are the existing conditions these people have? *

Back Pain: 9 people, 36.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 36.00%
Parkinson's Disease: 9 people, 36.00%
Dry Eyes (lack of adequate tears): 8 people, 32.00%
Dry Mouth: 8 people, 32.00%
Muscle Spasms (muscle contraction): 8 people, 32.00%
Nausea (feeling of having an urge to vomit): 7 people, 28.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 28.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 7 people, 28.00%
Urinary Tract Infection: 7 people, 28.00%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Urine output increased?

- Check whether Urine output increased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Browse all side effects of Benadryl:

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Browse all the drugs that are associated with Urine output increased:

Urine output increased (310 drugs)

Browse all the conditions that are associated with Urine output increased:

Urine output increased (573 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.