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Benlysta and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Benlysta (belimumab), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Prednisone, and have Depression.

The phase IV clinical study analyzes which people have Osteoporosis when taking Benlysta. It is created by eHealthMe based on reports of 23,452 people who have side effects when taking Benlysta from the FDA, and is updated regularly.

What is Benlysta?

Benlysta has active ingredients of belimumab. It is often used in systemic lupus erythematosus. eHealthMe is studying from 23,528 Benlysta users. Check the latest studies of Benlysta.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,814 drugs and 1,900 conditions by eHealthMe. Check the latest studies of Osteoporosis.

On Jul, 04, 2026

23,452 people reported to have side effects when taking Benlysta.
Among them, 48 people (0.2%) have Osteoporosis.

Could Benlysta cause Osteoporosis?

Among these 48 people:

How long have people been on Benlysta when they have Osteoporosis? *

  • < 1 month: 25 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 25 %
  • 10+ years: 0.0 %

What is the gender of people who have Osteoporosis when taking Benlysta? *

  • female: 90.32 %
  • male: 9.68 %

What is the age of people who have Osteoporosis when taking Benlysta? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 18.75 %
  • 50-59: 75.0 %
  • 60+: 6.25 %

What are other drugs people take besides Benlysta? *

  1. Methotrexate: 8 people, 16.67%
  2. Prednisone: 8 people, 16.67%
  3. Azathioprine: 5 people, 10.42%
  4. Calcium: 5 people, 10.42%
  5. Vitamin D: 3 people, 6.25%
  6. Plaquenil: 3 people, 6.25%
  7. Zoloft: 2 people, 4.17%
  8. Myfortic: 2 people, 4.17%
  9. Fluoxetine: 2 people, 4.17%
  10. Lisinopril: 2 people, 4.17%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 31 people, 64.58%
  2. Joint Pain: 25 people, 52.08%
  3. Dyspnea (difficult or laboured breathing): 24 people, 50.00%
  4. Back Pain: 23 people, 47.92%
  5. Malaise (a feeling of general discomfort or uneasiness): 21 people, 43.75%
  6. Pneumonia: 17 people, 35.42%
  7. Rashes (redness): 17 people, 35.42%
  8. High Blood Pressure: 15 people, 31.25%
  9. Fever: 15 people, 31.25%
  10. Pain In Extremity: 15 people, 31.25%

What are the existing conditions these people have? *

  1. High Blood Pressure: 4 people, 8.33%
  2. Depression: 4 people, 8.33%
  3. Renal Impairment (severely reduced kidney function): 2 people, 4.17%
  4. Pain: 2 people, 4.17%
  5. Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 4.17%
  6. High Blood Cholesterol: 2 people, 4.17%
  7. Gastric Disorder (disease of stomach): 2 people, 4.17%
  8. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 2.08%
  9. Mood Swings (an extreme or rapid change in mood): 1 person, 2.08%
  10. Lupus-Like Syndrome (a disease symptom matches with lupus an immune disease): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Benlysta and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benlysta:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of belimumab:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Benlysta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on belimumab (the active ingredients of Benlysta) and Benlysta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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