Benzonatate and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Benzonatate (benzonatate), especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years also take Prevacid, and have Narcolepsy.

The phase IV clinical study analyzes which people have Major depression when taking Benzonatate. It is created by eHealthMe based on reports of 16,665 people who have side effects when taking Benzonatate from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 800 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

On Aug, 04, 2026

16,665 people reported to have side effects when taking Benzonatate.
Among them, 11 people (0.07%) have Major depression.

Could Benzonatate cause Major depression?

Among these 11 people:

How long have people been on Benzonatate when they have Major depression? *

What is the gender of people who have Major depression when taking Benzonatate? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Major depression when taking Benzonatate? *

What are other drugs people take besides Benzonatate? *

What are other side effects people have besides Major depression? *

Stress And Anxiety: 7 people, 63.64%
Memory Loss: 5 people, 45.45%
Neuralgia (pain in one or more nerves): 4 people, 36.36%
Fatigue (feeling of tiredness): 3 people, 27.27%
Depression: 3 people, 27.27%
Asthma: 3 people, 27.27%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 27.27%
Bipolar Disorder (mood disorder): 3 people, 27.27%
Insomnia (sleeplessness): 3 people, 27.27%
Loss Of Consciousness: 3 people, 27.27%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 45.45%
Asthma: 4 people, 36.36%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 27.27%
Insomnia (sleeplessness): 3 people, 27.27%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 2 people, 18.18%
Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 2 people, 18.18%
Depression: 2 people, 18.18%
Diabetes: 2 people, 18.18%
Dizziness: 2 people, 18.18%
Dyspnea (difficult or laboured breathing): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Benzonatate and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benzonatate:

Benzonatate (17,274 reports)

Major depression treatments and more:

Major depression (44,981 reports)

Browse all side effects of Benzonatate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (800 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on benzonatate (the active ingredients of Benzonatate) and Benzonatate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.