Bijuva and Fatigue aggravated - a phase IV clinical study of FDA data

Summary:

Fatigue aggravated is reported as a side effect among people who take Bijuva (estradiol; progesterone), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Metformin, and have Hot flush.

The phase IV clinical study analyzes which people have Fatigue aggravated when taking Bijuva. It is created by eHealthMe based on reports of 476 people who have side effects when taking Bijuva from the FDA, and is updated regularly.

What is Bijuva?

Bijuva has active ingredients of estradiol; progesterone. eHealthMe is studying from 481 Bijuva users. Check the latest studies of Bijuva.

What is Fatigue aggravated?

Fatigue aggravated (feeling of tiredness) is found to be associated with 3,137 drugs and 1,116 conditions by eHealthMe. Check the latest studies of Fatigue aggravated.

On Jul, 30, 2026

476 people reported to have side effects when taking Bijuva.
Among them, 20 people (4.2%) have Fatigue aggravated.

Among these 20 people:

How long have people been on Bijuva when they have Fatigue aggravated? *

What is the gender of people who have Fatigue aggravated when taking Bijuva? *

female: 100 %
male: 0.0 %

What is the age of people who have Fatigue aggravated when taking Bijuva? *

What are other drugs people take besides Bijuva? *

What are other side effects people have besides Fatigue aggravated? *

Headache (pain in head): 7 people, 35.00%
Dizziness: 5 people, 25.00%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 20.00%
Feeling Abnormal: 4 people, 20.00%
Insomnia (sleeplessness): 4 people, 20.00%
Abdominal Discomfort: 4 people, 20.00%
Depressed Mood: 3 people, 15.00%
Drowsiness: 3 people, 15.00%
Back Pain: 3 people, 15.00%
Weakness: 3 people, 15.00%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 6 people, 30.00%
Menopause (end of monthly cycles in women): 4 people, 20.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 10.00%
Postmenopause: 1 person, 5.00%
Night Sweats (sweating in night): 1 person, 5.00%
Feeling Hot: 1 person, 5.00%
Drowsiness: 1 person, 5.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Bijuva and have Fatigue aggravated?

- Check whether Fatigue aggravated is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bijuva:

Bijuva (481 reports)

Browse all side effects of Bijuva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue aggravated:

Fatigue aggravated (3,138 drugs)

Browse all the conditions that are associated with Fatigue aggravated:

Fatigue aggravated (1,116 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; progesterone (the active ingredients of Bijuva) and Bijuva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.