Brexpiprazole and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Brexpiprazole (brexpiprazole), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Clozapine, and have Schizophrenia.

The phase IV clinical study analyzes which people have Malaise when taking Brexpiprazole. It is created by eHealthMe based on reports of 1,162 people who have side effects when taking Brexpiprazole from the FDA, and is updated regularly.

What is Brexpiprazole?

Brexpiprazole has active ingredients of brexpiprazole. eHealthMe is studying from 1,164 Brexpiprazole users. Check the latest studies of Brexpiprazole.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,513 drugs and 5,119 conditions by eHealthMe. Check the latest studies of Malaise.

On Jul, 15, 2026

1,162 people reported to have side effects when taking Brexpiprazole.
Among them, 40 people (3.44%) have Malaise.

Among these 40 people:

How long have people been on Brexpiprazole when they have Malaise? *

What is the gender of people who have Malaise when taking Brexpiprazole? *

female: 44.12 %
male: 55.88 %

What is the age of people who have Malaise when taking Brexpiprazole? *

What are other drugs people take besides Brexpiprazole? *

Zopiclone: 15 people, 37.50%
Risperidone: 15 people, 37.50%
Clozapine: 15 people, 37.50%
Amisulpride: 13 people, 32.50%
Aripiprazole: 13 people, 32.50%
Acetaminophen: 12 people, 30.00%
Diazepam: 12 people, 30.00%
Chlorpromazine Hydrochloride: 9 people, 22.50%
Venlafaxine Hydrochloride: 7 people, 17.50%
Valproate Sodium: 7 people, 17.50%

What are other side effects people have besides Malaise? *

Drug Ineffective: 16 people, 40.00%
Myocarditis (inflammation of heart muscle myocardium): 15 people, 37.50%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 14 people, 35.00%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 14 people, 35.00%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 14 people, 35.00%
Suicidal Ideation: 13 people, 32.50%
Arrhythmias (irregular heartbeat): 13 people, 32.50%
Persecutory Delusion: 12 people, 30.00%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 12 people, 30.00%
Troponin Increased: 12 people, 30.00%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 17.50%
Agitation (state of anxiety or nervous excitement): 6 people, 15.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 6 people, 15.00%
Hyperprolactinaemia (abnormally high levels of prolactin in the blood): 6 people, 15.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 12.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 12.50%
Insomnia (sleeplessness): 5 people, 12.50%
Gynecomastia (enlargement of the gland tissue of the male breast): 4 people, 10.00%
Erection Problems: 4 people, 10.00%
Depression: 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

Do you take Brexpiprazole and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Brexpiprazole:

Brexpiprazole (1,164 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Brexpiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,513 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,119 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brexpiprazole (the active ingredients of Brexpiprazole) and Brexpiprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.