Bupivacaine and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Bupivacaine (bupivacaine hydrochloride), especially for people who are male, 60+ old, also take Propofol, and have Anaesthesia.

The phase IV clinical study analyzes which people have Fluid retention when taking Bupivacaine. It is created by eHealthMe based on reports of 14,005 people who have side effects when taking Bupivacaine from the FDA, and is updated regularly.

What is Bupivacaine?

Bupivacaine has active ingredients of bupivacaine hydrochloride. eHealthMe is studying from 14,046 Bupivacaine users. Check the latest studies of Bupivacaine.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,698 drugs and 2,448 conditions by eHealthMe. Check the latest studies of Fluid retention.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

14,005 people reported to have side effects when taking Bupivacaine.
Among them, 24 people (0.17%) have Fluid retention.

Could Bupivacaine cause Fluid retention?

Among these 24 people:

What is the gender of people who have Fluid retention when taking Bupivacaine? *

female: 45.83 %
male: 54.17 %

What is the age of people who have Fluid retention when taking Bupivacaine? *

What are other drugs people take besides Bupivacaine? *

What are other side effects people have besides Fluid retention? *

Haemorrhage (bleeding): 12 people, 50.00%
Creatinine Renal Clearance Decreased: 8 people, 33.33%
Renin Increased: 8 people, 33.33%
Urine Output Decreased: 8 people, 33.33%
Sodium Retention: 8 people, 33.33%
Fatigue (feeling of tiredness): 7 people, 29.17%
Joint Swelling: 7 people, 29.17%
Joint Pain: 5 people, 20.83%
Fall: 5 people, 20.83%
Dizziness: 5 people, 20.83%

What are the existing conditions these people have? *

Anaesthesia: 10 people, 41.67%
Epidural Anaesthesia: 8 people, 33.33%
Depression: 4 people, 16.67%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
Back Pain: 3 people, 12.50%
Blood Testosterone Decreased: 3 people, 12.50%
Chest Pain: 3 people, 12.50%
Constipation: 3 people, 12.50%
Diabetes: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Bupivacaine and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bupivacaine:

Bupivacaine (14,046 reports)

Fluid retention treatments and more:

Fluid retention (79,661 reports)

Browse all side effects of Bupivacaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,698 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,448 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupivacaine hydrochloride (the active ingredients of Bupivacaine) and Bupivacaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.