Caffeine and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Caffeine (caffeine), especially for people who are male, 10-19 old, also take Ondansetron, and have Suicide attempt.

The phase IV clinical study analyzes which people have Mental status changes when taking Caffeine. It is created by eHealthMe based on reports of 6,333 people who have side effects when taking Caffeine from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,498 drugs and 1,759 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Jul, 13, 2026

6,333 people reported to have side effects when taking Caffeine.
Among them, 52 people (0.82%) have Mental status changes.

Could Caffeine cause Mental status changes?

Among these 52 people:

What is the gender of people who have Mental status changes when taking Caffeine? *

female: 34.04 %
male: 65.96 %

What is the age of people who have Mental status changes when taking Caffeine? *

What are other drugs people take besides Caffeine? *

What are other side effects people have besides Mental status changes? *

Overdose: 28 people, 53.85%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 24 people, 46.15%
Cardiac Arrest: 24 people, 46.15%
Hypotension (abnormally low blood pressure): 21 people, 40.38%
Suicide Attempt: 16 people, 30.77%
Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney): 10 people, 19.23%
Loss Of Consciousness: 10 people, 19.23%
Torsade De Pointes (a abnormal heart rate with abnormal beating pattern): 10 people, 19.23%
Arrhythmias (irregular heartbeat): 10 people, 19.23%
Ventricular Fibrillation (abnormally irregular heart rhythm): 9 people, 17.31%

What are the existing conditions these people have? *

Suicide Attempt: 8 people, 15.38%
Insomnia (sleeplessness): 6 people, 11.54%
Headache (pain in head): 4 people, 7.69%
Sleep Disorder: 2 people, 3.85%
Depression: 2 people, 3.85%
Spinal Stenosis (narrowing of spinal column): 1 person, 1.92%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 1.92%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 1.92%
Pain: 1 person, 1.92%
Overdose: 1 person, 1.92%

* Approximation only. Some reports may have incomplete information.

Do you take Caffeine and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Caffeine:

Caffeine (6,667 reports)

Browse all side effects of Caffeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,498 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on caffeine (the active ingredients of Caffeine) and Caffeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.