Carbidopa and levodopa and Paranoia - a phase IV clinical study of FDA data

Summary:

Paranoia is reported as a side effect among people who take Carbidopa and levodopa (carbidopa; levodopa), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Delusion.

The phase IV clinical study analyzes which people have Paranoia when taking Carbidopa and levodopa. It is created by eHealthMe based on reports of 5,664 people who have side effects when taking Carbidopa and levodopa from the FDA, and is updated regularly.

What is Carbidopa and levodopa?

Carbidopa and levodopa has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 6,152 Carbidopa and levodopa users. Check the latest studies of Carbidopa and levodopa.

What is Paranoia?

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur) is found to be associated with 1,041 drugs and 1,276 conditions by eHealthMe. Check the latest studies of Paranoia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

5,664 people reported to have side effects when taking Carbidopa and levodopa.
Among them, 25 people (0.44%) have Paranoia.

Could Carbidopa and levodopa cause Paranoia?

Among these 25 people:

How long have people been on Carbidopa and levodopa when they have Paranoia? *

What is the gender of people who have Paranoia when taking Carbidopa and levodopa? *

female: 60 %
male: 40 %

What is the age of people who have Paranoia when taking Carbidopa and levodopa? *

What are other drugs people take besides Carbidopa and levodopa? *

What are other side effects people have besides Paranoia? *

Hallucinations (sensations that appear real but are created by your mind): 12 people, 48.00%
Confusional State: 7 people, 28.00%
Hallucination, Visual (seeing things that aren't there): 4 people, 16.00%
Drowsiness: 4 people, 16.00%
Delusion (a false belief or opinion): 4 people, 16.00%
Fall: 4 people, 16.00%
Stress And Anxiety: 4 people, 16.00%
Agitation (state of anxiety or nervous excitement): 3 people, 12.00%
Balance Disorder: 3 people, 12.00%
Drug Ineffective: 3 people, 12.00%

What are the existing conditions these people have? *

Hallucinations (sensations that appear real but are created by your mind): 11 people, 44.00%
Delusion (a false belief or opinion): 11 people, 44.00%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 4.00%
Stress And Anxiety: 1 person, 4.00%
Psychotic Disorder: 1 person, 4.00%
Memory Loss: 1 person, 4.00%
Gout (uric acid crystals building up in the body): 1 person, 4.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 4.00%
Dementia (madness): 1 person, 4.00%
Calcinosis (calcium deposits in any soft tissue): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Carbidopa and levodopa and have Paranoia?

- Check whether Paranoia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Carbidopa and levodopa:

Carbidopa and levodopa (6,152 reports)

Paranoia treatments and more:

Paranoia (23,921 reports)

Browse all side effects of Carbidopa and levodopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paranoia:

Paranoia (1,041 drugs)

Browse all the conditions that are associated with Paranoia:

Paranoia (1,276 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Carbidopa and levodopa) and Carbidopa and levodopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.