Ceftriaxone and Herpes simplex aggravated - a phase IV clinical study of FDA data

Summary:

Herpes simplex aggravated is reported as a side effect among people who take Ceftriaxone (ceftriaxone sodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Whipple's disease.

The phase IV clinical study analyzes which people have Herpes simplex aggravated when taking Ceftriaxone. It is created by eHealthMe based on reports of 40,872 people who have side effects when taking Ceftriaxone from the FDA, and is updated regularly.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

What is Herpes simplex aggravated?

Herpes simplex aggravated (serious herpes simplex is a common viral infection) is found to be associated with 703 drugs and 290 conditions by eHealthMe. Check the latest studies of Herpes simplex aggravated.

On Jul, 30, 2026

40,872 people reported to have side effects when taking Ceftriaxone.
Among them, 44 people (0.11%) have Herpes simplex aggravated.

Could Ceftriaxone cause Herpes simplex aggravated?

Among these 44 people:

How long have people been on Ceftriaxone when they have Herpes simplex aggravated? *

What is the gender of people who have Herpes simplex aggravated when taking Ceftriaxone? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Herpes simplex aggravated when taking Ceftriaxone? *

What are other drugs people take besides Ceftriaxone? *

Bactrim: 9 people, 20.45%
Prednisolone: 5 people, 11.36%
Sulfamethoxazole And Trimethoprim: 5 people, 11.36%
Halothane: 4 people, 9.09%
Doxycycline: 4 people, 9.09%
Acyclovir: 4 people, 9.09%
Bupivacaine: 4 people, 9.09%
Cefotaxime Sodium: 3 people, 6.82%
Metformin: 3 people, 6.82%
Hydroxychloroquine Sulfate: 3 people, 6.82%

What are other side effects people have besides Herpes simplex aggravated? *

Fever: 13 people, 29.55%
Staphylococcal Infection (an infection with staphylococcus bacteria): 6 people, 13.64%
Confusion: 6 people, 13.64%
Tumor: 6 people, 13.64%
Febrile Neutropenia (fever with reduced white blood cells): 6 people, 13.64%
Panniculitis (inflammation of the subcutaneous fat): 5 people, 11.36%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 5 people, 11.36%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 5 people, 11.36%
Cough: 5 people, 11.36%
Erythema Nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below): 5 people, 11.36%

What are the existing conditions these people have? *

Whipple's Disease (infection with a bacteria called tropheryma whippelii): 8 people, 18.18%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 13.64%
Fever: 4 people, 9.09%
High Blood Pressure: 3 people, 6.82%
Type 2 Diabetes: 3 people, 6.82%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 6.82%
Asthma: 2 people, 4.55%
B-Cell Unclassifiable Lymphoma Low Grade (rapidly progressing unclassifiable b-cell cancer difficult to treat - low grade): 2 people, 4.55%
Breast Cancer Recurrent: 2 people, 4.55%
Cellulitis (infection under the skin): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Ceftriaxone and have Herpes simplex aggravated?

- Check whether Herpes simplex aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ceftriaxone:

Ceftriaxone (40,991 reports)

Browse all side effects of Ceftriaxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Herpes simplex aggravated:

Herpes simplex aggravated (703 drugs)

Browse all the conditions that are associated with Herpes simplex aggravated:

Herpes simplex aggravated (290 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Ceftriaxone) and Ceftriaxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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