Ceftriaxone and Hypertonia - a phase IV clinical study of FDA data

Summary:

Hypertonia is reported as a side effect among people who take Ceftriaxone (ceftriaxone sodium), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Acyclovir, and have Lupus nephritis.

The phase IV clinical study analyzes which people have Hypertonia when taking Ceftriaxone. It is created by eHealthMe based on reports of 40,872 people who have side effects when taking Ceftriaxone from the FDA, and is updated regularly.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

What is Hypertonia?

Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch) is found to be associated with 487 drugs and 695 conditions by eHealthMe. Check the latest studies of Hypertonia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

40,872 people reported to have side effects when taking Ceftriaxone.
Among them, 27 people (0.07%) have Hypertonia.

Among these 27 people:

How long have people been on Ceftriaxone when they have Hypertonia? *

What is the gender of people who have Hypertonia when taking Ceftriaxone? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Hypertonia when taking Ceftriaxone? *

What are other drugs people take besides Ceftriaxone? *

What are other side effects people have besides Hypertonia? *

Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 25.93%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 22.22%
Agitation (state of anxiety or nervous excitement): 6 people, 22.22%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 5 people, 18.52%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 18.52%
Confusional State: 5 people, 18.52%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 4 people, 14.81%
Photophobia (extreme sensitivity to light): 4 people, 14.81%
Blindness Cortical: 4 people, 14.81%
Headache (pain in head): 4 people, 14.81%

What are the existing conditions these people have? *

Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 4 people, 14.81%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 11.11%
Acute Kidney Failure: 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
Rashes (redness): 2 people, 7.41%
Bacterial Infection: 2 people, 7.41%
Encephalitis Viral (inflammation of the brain due to viral infection): 2 people, 7.41%
Infection: 2 people, 7.41%
Borrelia Infection (infectious disease caused by bacteria belonging to the genus borrelia): 1 person, 3.70%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Ceftriaxone and have Hypertonia?

- Check whether Hypertonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ceftriaxone:

Ceftriaxone (40,991 reports)

Hypertonia treatments and more:

Hypertonia (11,073 reports)

Browse all side effects of Ceftriaxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertonia:

Hypertonia (487 drugs)

Browse all the conditions that are associated with Hypertonia:

Hypertonia (695 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Ceftriaxone) and Ceftriaxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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