Centrum silver and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Fish Oil, and have Metastatic renal cell carcinoma.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,996 Centrum silver users. Check the latest studies of Centrum silver.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 872 drugs and 915 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Feb, 03, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 17 people (0.09%) have Hyperaesthesia.

Could Centrum silver cause Hyperaesthesia?

Among these 17 people:

What is the gender of people who have Hyperaesthesia when taking Centrum silver? *

female: 68.75 %
male: 31.25 %

What is the age of people who have Hyperaesthesia when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

What are other side effects people have besides Hyperaesthesia? *

Diarrhea: 7 people, 41.18%
Hyperkeratosis (thickening of the outer layer of the skin): 6 people, 35.29%
Pain In Extremity: 6 people, 35.29%
Hair Loss: 6 people, 35.29%
Gums - Swollen: 5 people, 29.41%
Burning Sensation: 5 people, 29.41%
Rashes (redness): 5 people, 29.41%
Scab (a hard coating on the skin formed during the wound healing): 5 people, 29.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 29.41%
Joint Pain: 5 people, 29.41%

What are the existing conditions these people have? *

Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 4 people, 23.53%
High Blood Pressure: 3 people, 17.65%
High Blood Cholesterol: 1 person, 5.88%
Asthma: 1 person, 5.88%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 1 person, 5.88%
Blood Pressure Abnormal: 1 person, 5.88%
Breast Cancer: 1 person, 5.88%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.88%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Hyperaesthesia?

- Check whether Hyperaesthesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,996 reports)

Hyperaesthesia treatments and more:

Hyperaesthesia (10,827 reports)

How severe was Hyperaesthesia and when was it recovered:

Hyperaesthesia in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Hyperaesthesia and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (247 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperaesthesia:

Hyperaesthesia (872 drugs)

Browse all the conditions that are associated with Hyperaesthesia:

Hyperaesthesia (915 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.