Centrum silver and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Percocet, and have Osteoporosis.

The phase IV clinical study analyzes which people have Joint stiffness when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,301 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 42 people (0.22%) have Joint stiffness.

Could Centrum silver cause Joint stiffness?

Among these 42 people:

What is the gender of people who have Joint stiffness when taking Centrum silver? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Joint stiffness when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

What are other side effects people have besides Joint stiffness? *

Joint Pain: 29 people, 69.05%
Joint Swelling: 21 people, 50.00%
Constipation: 16 people, 38.10%
Nausea (feeling of having an urge to vomit): 15 people, 35.71%
Muscle Aches (muscle pain): 14 people, 33.33%
Fall: 14 people, 33.33%
Pain In Extremity: 14 people, 33.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 13 people, 30.95%
Femur Fracture: 13 people, 30.95%
Back Pain: 12 people, 28.57%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 8 people, 19.05%
Metastases To Bone (cancer spreads to bone): 7 people, 16.67%
Breast Cancer: 7 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 16.67%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.52%
High Blood Pressure: 4 people, 9.52%
Asthma: 3 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,997 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

How severe was Joint stiffness and when was it recovered:

Joint stiffness in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Joint stiffness and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (820 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,301 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.