Centrum silver and Macular oedema - a phase IV clinical study of FDA data

Summary:

Macular oedema is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Gilenya, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Macular oedema when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Macular oedema?

Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken) is found to be associated with 434 drugs and 860 conditions by eHealthMe. Check the latest studies of Macular oedema.

On Aug, 01, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 11 people (0.06%) have Macular oedema.

Could Centrum silver cause Macular oedema?

Among these 11 people:

What is the gender of people who have Macular oedema when taking Centrum silver? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Macular oedema when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

What are other side effects people have besides Macular oedema? *

Visual Impairment: 5 people, 45.45%
Hemiparesis (weakness on one side of the body): 3 people, 27.27%
Confusional State: 3 people, 27.27%
Itching: 2 people, 18.18%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 18.18%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 18.18%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 2 people, 18.18%
Photophobia (extreme sensitivity to light): 2 people, 18.18%
Dizziness: 2 people, 18.18%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 18.18%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 45.45%
Depression: 3 people, 27.27%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 18.18%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 18.18%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Constipation: 2 people, 18.18%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 2 people, 18.18%
Essential Tremor: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Macular oedema?

- Check whether Macular oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,997 reports)

Macular oedema treatments and more:

Macular oedema (10,661 reports)

How severe was Macular oedema and when was it recovered:

Macular oedema in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Macular oedema and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (86 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macular oedema:

Macular oedema (434 drugs)

Browse all the conditions that are associated with Macular oedema:

Macular oedema (860 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.