Centrum silver and Orthostatic hypotension - a phase IV clinical study of FDA data

Summary:

Orthostatic hypotension is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are male, 60+ old, also take Acetaminophen, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Orthostatic hypotension when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Orthostatic hypotension?

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up) is found to be associated with 1,225 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Orthostatic hypotension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 26 people (0.13%) have Orthostatic hypotension.

Could Centrum silver cause Orthostatic hypotension?

Among these 26 people:

What is the gender of people who have Orthostatic hypotension when taking Centrum silver? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Orthostatic hypotension when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

Zometa: 7 people, 26.92%
Ambien: 7 people, 26.92%
Acetaminophen: 7 people, 26.92%
Aredia: 6 people, 23.08%
Percocet: 6 people, 23.08%
Thalidomide: 6 people, 23.08%
Prednisone: 5 people, 19.23%
Viagra: 5 people, 19.23%
Chlorhexidine Gluconate: 4 people, 15.38%
Synthroid: 4 people, 15.38%

What are other side effects people have besides Orthostatic hypotension? *

Dizziness: 14 people, 53.85%
Fainting (loss of consciousness and postural tone): 10 people, 38.46%
Diarrhea: 10 people, 38.46%
Cataract (clouding of the lens inside the eye): 8 people, 30.77%
Hyperlipidaemia (presence of excess lipids in the blood): 8 people, 30.77%
Anaemia (lack of blood): 8 people, 30.77%
Stress And Anxiety: 7 people, 26.92%
Gait Disturbance: 7 people, 26.92%
Thrombocytopenia (decrease of platelets in blood): 7 people, 26.92%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 23.08%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 34.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
High Blood Cholesterol: 3 people, 11.54%
Pain: 3 people, 11.54%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 11.54%
Neoplasm Malignant (cancer tumour): 3 people, 11.54%
Erection Problems: 2 people, 7.69%
Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 2 people, 7.69%
Hyperhomocysteinaemia (abnormally high level of homocysteine in the blood): 2 people, 7.69%
Osteoporosis (bones weak and more likely to break): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Orthostatic hypotension?

- Check whether Orthostatic hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,997 reports)

Orthostatic hypotension treatments and more:

Orthostatic hypotension (30,627 reports)

How severe was Orthostatic hypotension and when was it recovered:

Orthostatic hypotension in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Orthostatic hypotension and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (504 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,225 drugs)

Browse all the conditions that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,336 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.